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HomeProduct name listRink Amide Linker

Rink Amide Linker

Synonym(s):Rink amide linker

  • CAS NO.:145069-56-3
  • Empirical Formula: C32H29NO7
  • Molecular Weight: 539.58
  • MDL number: MFCD00153509
  • EINECS: 604-455-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-11-16 17:07:08
Rink Amide Linker Structural

What is Rink Amide Linker?

The Uses of Rink Amide Linker

Rink amide linker (CAS# 145069-56-3) is a selective aldose reductase inhibitor and a potential antidiabetic drug.

What are the applications of Application

Most linkers are bifunctional spacers, with one end permanently anchoring to the resin and the other end temporarily linking to the peptide. Peptides anchoring to Rink linker can be easily cleaved under acidic conditions. Since the discovery of Rink linker, it has been grafted to a variety of resins and widely used for scientific investigations and industrial solid-phase peptide synthesis. Thus, Rink Amide Linker is the key reagent to prepare this series of Rink-resins[1].

Origin

Rink Amide Linker was first designed by Rink and further developed by Bernatowicz and co-workers for the preparation of peptide C-terminal amides[1]. Rink Amide Linker is also known as commercial Knorr linker.

References

[1] Qin L, et al. An improved and practical synthesis of Fmoc Rink linker. Journal of Chemical Research, 2019.

Properties of Rink Amide Linker

Melting point: ~180 °C (dec.)
storage temp.  2-8°C
solubility  Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form  Powder
BRN  5841553
CAS DataBase Reference 145069-56-3(CAS DataBase Reference)

Safety information for Rink Amide Linker

Computed Descriptors for Rink Amide Linker

InChIKey UPMGJEMWPQOACJ-UHFFFAOYSA-N
SMILES C(O)(=O)COC1=CC=C(C(C2=CC=C(OC)C=C2OC)NC(OCC2C3C(=CC=CC=3)C3C2=CC=CC=3)=O)C=C1

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