4'-(2-Methylpropyl)acetophenone
Synonym(s):1-(4-Isobutylphenyl)ethanone;1-Acetyl-4-isobutylbenzene
- CAS NO.：38861-78-8
- Empirical Formula: C12H16O
- Molecular Weight: 176.25
- MDL number: MFCD00027393
- EINECS: 254-159-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:57
What is 4'-(2-Methylpropyl)acetophenone?
Chemical properties
Clear Colourless Oil
The Uses of 4'-(2-Methylpropyl)acetophenone
A degradation product of Ibuprofen in tablets, which is a known toxin. Ibuprofen (I140000) impuritiy.
The Uses of 4'-(2-Methylpropyl)acetophenone
4'-isobutylacetophenone is an important starting material employed in the production of pharmaceuticals such as ibuprofen. It is also utilized in proteomics research. It is used as an intermediate in organic synthesis.
Preparation
Synthesis of 4-isobutylacetophenone: toluene and propylene are reacted with the participation of metal potassium, sodium carbonate and graphite, Alkylation on methyl to generate isobutylbenzene, Then with acetyl chloride in the participation of anhydrous aluminum trichloride to obtain the product.
General Description
4'-(2-Methylpropyl)acetophenone, also known as Ibuprofen EP Impurity E, is an impurity of ibuprofen. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation.
Properties of 4'-(2-Methylpropyl)acetophenone
| Boiling point: | 134-135°C 16mm |
| Density | 0,952 g/cm3 |
| vapor pressure | 0.75Pa at 20℃ |
| refractive index | 1.5180 |
| Flash point: | 54°C |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Dichloromethane; Diethyl Ether; Ethyl Acetate; THF |
| form | neat |
| color | Colorless to Yellow |
| Water Solubility | Miscible with chloroform and methanol. Slightly miscible with water. |
| BRN | 1935275 |
| InChI | InChI=1S/C12H16O/c1-9(2)8-11-4-6-12(7-5-11)10(3)13/h4-7,9H,8H2,1-3H3 |
| CAS DataBase Reference | 38861-78-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 4'-(2-Methylpropyl)acetophenone(38861-78-8) |
| EPA Substance Registry System | Ethanone, 1-[4-(2-methylpropyl)phenyl]- (38861-78-8) |
Safety information for 4'-(2-Methylpropyl)acetophenone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H317:Sensitisation, Skin H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P272:Contaminated work clothing should not be allowed out of the workplace. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for 4'-(2-Methylpropyl)acetophenone
| InChIKey | KEAGRYYGYWZVPC-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC=C(CC(C)C)C=C1)C |
4'-(2-Methylpropyl)acetophenone manufacturer
JSK Chemicals
2Y
Phone:+919879767970
Whatsapp: +91 9879767970
product: 4'-Isobutylacetophenone, 97% 99%
Varanous Labs Pvt Ltd
1Y
Phone:+917036248882
Whatsapp: +91 7036248882
product: Ibuprofen EP Impurity E 38861-78-8 98%
Syn Finechem Laboratories Pvt Ltd.
1Y
Phone:+91-9848230784
Whatsapp: +91 9848230784
product: 38861-78-8 98%
ALS INDIA LIFE SCIENCES
1Y
Phone:+91-8977036379
Whatsapp: +91 8008166674
product: 4-Isobutylacetophenone 98%
IOL Chemicals And Pharmaceuticals Limited
1Y
Phone:+91-9878996045
Whatsapp: +91- 9878996045
product: 38861-78-8 4-Isobutylacetophenone 98%
Clickchem Research LLP
1Y
Phone:+91-8140031133
Whatsapp: +91- 8140031133
product: 38861-78-8 4-ISOBUTYLACETOPHENONE 90 % Above
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate N-octanoyl benzotriazole 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5,6-Dimethoxyindanone 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
![2-[4-(2-Methylpropyl)phenyl] ethanol](https://img.chemicalbook.in/CAS/20130318/GIF/CB12605071.gif)
You may like
-
4'-Isobutylacetophenone, 97% 99%View Details
38861-78-8 -
Ibuprofen EP Impurity E 38861-78-8 98%View Details
38861-78-8 -
4-Isobutylacetophenone 98%View Details
38861-78-8 -
38861-78-8 4-Isobutylacetophenone 98%View Details
38861-78-8 -
4-Isobutylacetophenone 98%View Details
-
38861-78-8 98%View Details
38861-78-8 -
4'-Isobutylacetophenone CAS 38861-78-8View Details
38861-78-8 -
Ibuprofen Related Compound C CAS 38861-78-8View Details
38861-78-8
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.