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HomeProduct name list2-(4-Methylphenyl)propanoic acid

2-(4-Methylphenyl)propanoic acid

Synonym(s):2-(4-Methylphenyl)propanoic acid;Ibuprofen Impurity D (Ph. Eur.);Ibuprofen impurity D (PhEur);α,4-Dimethylphenylacetic acid;(2RS)-2-(4-Methylphenyl)propionic acid

  • CAS NO.:938-94-3
  • Empirical Formula: C10H12O2
  • Molecular Weight: 164.2
  • MDL number: MFCD01111378
  • EINECS: 627-324-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-04-16 16:04:49
2-(4-Methylphenyl)propanoic acid Structural

What is 2-(4-Methylphenyl)propanoic acid?

Chemical properties

clear yellow liquid after melting

The Uses of 2-(4-Methylphenyl)propanoic acid

2-(p-Tolyl)propionic acid is an impurity of Ibuprofen (I140000). Ibuprofen impurity D.

The Uses of 2-(4-Methylphenyl)propanoic acid

2-(p-Tolyl)propionic acid (Ibuprofen EP Impurity D) is an impurity of Ibuprofen (I140000). Ibuprofen impurity D.

Synthesis Reference(s)

Synthesis, p. 231, 1984 DOI: 10.1055/s-1984-30784
Tetrahedron Letters, 36, p. 5641, 1995 DOI: 10.1016/0040-4039(95)01035-G

General Description

α,4-Dimethylphenylacetic acid is also referred to as 2-(4-methylphenyl)propanoic acid. It is an alkaline decomposition product of azalomycin-B, a macrolide antibiotic produced by Streptomyces hygroscopicus var. azalomyceticus. The reaction of pinonic acid with bromine in water affords 2-(4-methylphenyl)propanoic acid.

Properties of 2-(4-Methylphenyl)propanoic acid

Melting point: 37-42 °C(lit.)
Boiling point: 231.67°C (rough estimate)
Density  1.0041 (rough estimate)
refractive index  1.518-1.52
Flash point: >230 °F
storage temp.  Sealed in dry,Room Temperature
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Solid
pka 4.44±0.10(Predicted)
color  White to Off-White Low-Melting
BRN  2251315
CAS DataBase Reference 938-94-3(CAS DataBase Reference)

Safety information for 2-(4-Methylphenyl)propanoic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-(4-Methylphenyl)propanoic acid

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