3,3-Dimethylallyl bromide

Synonym(s):1-Bromo-3-methyl-2-butene;Prenyl bromide

CAS NO.：870-63-3
Empirical Formula: C5H9Br
Molecular Weight: 149.03
MDL number: MFCD00000242
EINECS: 212-799-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-25 20:04:51

What is 3,3-Dimethylallyl bromide?

Chemical properties

3,3-Dimethylallyl bromide is colourless liquid

The Uses of 3,3-Dimethylallyl bromide

3,3-Dimethylallyl bromide is a useful source of the 3,3-dimethylallyl or prenyl group for the synthesis of natural products1 and in the synthesis of base-modified pyrimidine nucleosides.2

The Uses of 3,3-Dimethylallyl bromide

3,3-Dimethylallyl bromide has been used in the preparation of:

(±)-eldanolide
1-(3,3-dimethylallyl)-L-tryptophan
(±)-fumagillin, antibiotic isolated from Aspergillus fumigattus

The Uses of 3,3-Dimethylallyl bromide

3,3-Dimethylallyl bromide was used in the synthesis of 1- and 2-allylic-3-methylindoles. It was also used in the synthesis of products and base-modified pyrimidine nucleosides.

Properties of 3,3-Dimethylallyl bromide

Melting point:	-106.7°C (estimate)
Boiling point:	82-83 °C150 mm Hg(lit.)
Density	1.29 g/mL at 20 °C(lit.)
refractive index	n20/D 1.489(lit.)
Flash point:	88 °F
storage temp.	2-8°C
form	Liquid
Specific Gravity	1.27
color	Clear colorless, yellow or brown
Water Solubility	Immiscible with water
Sensitive	Light Sensitive
BRN	1420778
CAS DataBase Reference	870-63-3(CAS DataBase Reference)
NIST Chemistry Reference	2-Butene, 1-bromo-3-methyl-(870-63-3)
EPA Substance Registry System	2-Butene, 1-bromo-3-methyl- (870-63-3)

Safety information for 3,3-Dimethylallyl bromide

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Environment GHS09
GHS Hazard Statements	H226:Flammable liquids H314:Skin corrosion/irritation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.