Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

  • CAS NO.:1228779-96-1
  • Empirical Formula: C12H17N3O5S
  • Molecular Weight: 315.35
  • MDL number: MFCD28142285
  • EINECS: 1592732-453-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-04-03 10:18:12
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Structural

What is 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide?

The Uses of 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

3-?Nitro-?4-?(((tetrahydro-?2H-?pyran-?4-?yl)?methyl)?amino)?benzenesulfonamide is a reagent used in the synthesis of BTK, PI3K and JAK-2 inhibitors.

The Uses of 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is a pharmaceutical intermediate compound used in the preparation of Venetoclax, which is used to treat certain types of chronic lymphocytic leukaemia (CL) or certain types of small lymphocytic lymphoma (SLL).

Synthesis

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is prepared by the reaction of 4-Aminomethyltetrahydropyran and 4-Fluoro-3-nitrobenzenesulfonamide. The specific synthesis steps are as follows:
4-Fluoro-3-nitrobenzenesulfonamide (1.0 g, 4.54 mmol), (tetrahydro-2H-pyran-4-yl)methylamine (0.6 g, 4.49 mmol), Triethylamine (1.3 g, 6.81 mmol) was added to 10 ml of tetrahydrofuran solution. After stirring at room temperature for 5 h, the solvent was removed. Add 20ml of methanol to beat, After drying, the product was obtained in an amount of 1.4 g. The yield was 97percent.
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide synthesis

Properties of 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

Melting point: 188 - 191°C
Boiling point: 542.0±60.0 °C(Predicted)
Density  1.412±0.06 g/cm3(Predicted)
storage temp.  2-8°C(protect from light)
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 9.58±0.60(Predicted)
color  Yellow to Dark Yellow
CAS DataBase Reference 1228779-96-1

Safety information for 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

Related products of tetrahydrofuran

You may like

  • 1228779-96-1 3-Nitro-4-[(oxan-4-ylmethyl)amino]benzenesulfonamide 98%
    1228779-96-1 3-Nitro-4-[(oxan-4-ylmethyl)amino]benzenesulfonamide 98%
    1228779-96-1
    View Details
  • 1228779-96-1 98%
    1228779-96-1 98%
    1228779-96-1
    View Details
  • 3-Nitro-4-[(oxan-4-ylmethyl)amino]benzenesulfonamide 98%
    3-Nitro-4-[(oxan-4-ylmethyl)amino]benzenesulfonamide 98%
    View Details
  • 1975-50-4 98%
    1975-50-4 98%
    1975-50-4
    View Details
  • 2-HYDROXY BENZYL ALCOHOL 98%
    2-HYDROXY BENZYL ALCOHOL 98%
    90-01-7
    View Details
  • 14714-50-2 (2-Hydroxyphenyl)acetonitrile 98+
    14714-50-2 (2-Hydroxyphenyl)acetonitrile 98+
    14714-50-2
    View Details
  • 118753-70-1 98+
    118753-70-1 98+
    118753-70-1
    View Details
  • 733039-20-8 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 98+
    733039-20-8 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 98+
    733039-20-8
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.