1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol
- CAS NO.：685514-01-6
- Empirical Formula: C16H26N2OSi
- Molecular Weight: 290.48
- MDL number: MFCD11616408
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-29 15:21:39
![1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol Structural](https://img.chemicalbook.in/CAS/GIF/685514-01-6.gif)
What is 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol?
Synthesis
Add 10.8g (34mmol) of (1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)boronic acid and 120mL of tetrahydrofuran to a round bottom flask equipped with a magnetic stirrer, an inert gas source and a separating funnel, and stir to dissolve; Add 34mL of 1mol/L sodium hydroxide solution and 4.60g (40.6mmol) of 30% hydrogen peroxide dropwise at 0°C. After the addition, React at 0°C for 1 hour and detect the reaction by TLC. Add 4.8g (20.24mmol) of sodium thiosulfate, adjust to pH=5 with 2mol/L hydrochloric acid, extract with ethyl acetate (2x200mL), combine the organic phases, wash with saturated brine in turn, dry with a sodium sulfate, and reduce Concentrate under pressure. The residue was purified by silica gel column chromatography [eluent: dichloromethane] to obtain 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol 9.4g, yield 95.0%.![1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]-](/NewsImg/2024-03-29/6384732255355666584788284.png "1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]-")
Properties of 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol
| Boiling point: | 341.6±35.0 °C(Predicted) |
| Density | 1.03±0.1 g/cm3(Predicted) |
| pka | 8.50±0.40(Predicted) |
Safety information for 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P330:Rinse mouth. P362:Take off contaminated clothing and wash before reuse. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol
Abamectin manufacturer
Viyash Life Sciences Pvt Ltd
1Y
Phone:+91-4023635052
product: 685514-01-6 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol 98%
Lakshmi Farmachem
1Y
Phone:+91-9550886476
Whatsapp: +91-9550886476
product: 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol 98%
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
![4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde](https://img.chemicalbook.in/CAS/20150408/GIF/1228837-05-5.gif)
![Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate](https://img.chemicalbook.in/CAS/20180713/GIF/1235865-75-4.gif)
![1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine](https://img.chemicalbook.in/CAS/GIF/1228780-72-0.gif)
![2-[(1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoic acid](https://img.chemicalbook.in/CAS/20180713/GIF/1235865-77-6.gif)
![1H-PYRROLO[2,3-B]PYRIDIN-5-OL](https://img.chemicalbook.in/CAS/GIF/98549-88-3.gif)
You may like
-
![685514-01-6 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol 98%](https://img.chemicalbook.in//ProductImageIndia/2024-03/Raw/16d62c39-69fa-439a-ab06-baf3e6feeaa6.png)
685514-01-6 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol 98%View Details
685514-01-6 -
1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol 98%View Details
-
1823368-42-8 98%View Details
1823368-42-8 -
2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%View Details
1307449-08-6 -
Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%View Details
25408-95-1 -
2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%View Details
1805639-70-6 -
1784294-80-9 98%View Details
1784294-80-9 -
Lithium ClavulanateView Details
61177-44-4
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.