3'-Hydroxypropiophenone
- CAS NO.：13103-80-5
- Empirical Formula: C9H10O2
- Molecular Weight: 150.17
- MDL number: MFCD03428514
- EINECS: 236-027-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:54
What is 3'-Hydroxypropiophenone?
The Uses of 3'-Hydroxypropiophenone
1-?(3-?Hydroxyphenyl)?-?1-?propanone is a reactant used to synthesize tricyclic fused pyridines, a family of alkaloids with antimalarial activity.
Preparation
Preparation by diazotization of m-aminopropiophenone, followed by decomposition of the diazonium salt obtained, (71%)
Also obtained by saponification of 3-acetoxypropiophenone (b.p.2 127–128°) with refluxing 10% sodium hydroxide for 2–3 h (83%)
Also obtained by reductive deamination of 2-amino-5-hydroxypropiophenone (diazotization, followed by decomposition of the diazonium salt formed with copper powder in ethanol)
Also obtained by reaction of ethylmagnesium bromide with 3-hydroxy-N, N-diethylbenzamide in refluxing n-butyl ether for 4 h (75%)
Also obtained by treatment of 3-methoxypropiophenone (b.p.0.05 70–76°) with pyridinium chloride at 210° for 30 min (85%)
Also obtained by treatment of 1-hydroxy-1-(3-hydroxyphenyl)propane (m.p. 105–107°) with DDQ in dioxane for 72 h (97%).
Properties of 3'-Hydroxypropiophenone
| Melting point: | 82 °C |
| Boiling point: | 288.9±23.0 °C(Predicted) |
| Density | 1.104±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| pka | 9.09±0.10(Predicted) |
| form | Solid |
| color | Off-White to Beige |
| CAS DataBase Reference | 13103-80-5(CAS DataBase Reference) |
Safety information for 3'-Hydroxypropiophenone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3'-Hydroxypropiophenone
3'-Hydroxypropiophenone manufacturer
Clarion Drugs Ltd
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