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HomeProduct name list3-HYDROXYFLAVONE

3-HYDROXYFLAVONE

Synonym(s):Flavonol

  • CAS NO.:577-85-5
  • Empirical Formula: C15H10O3
  • Molecular Weight: 238.24
  • MDL number: MFCD00006832
  • EINECS: 209-416-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-09 19:38:33
3-HYDROXYFLAVONE Structural

What is 3-HYDROXYFLAVONE?

Chemical properties

yellow fluffy powder

The Uses of 3-HYDROXYFLAVONE

3-Hydroxyflavone is a reactant involved in studies of photochemically-induced dioxygenase-type CO-release reactivity; phase-transfer protection and deprotection of hydroxychromones; and O-methylation with di-Me carbonate. As a reactant it is involved in the synthesis of biologically active molecules including 2-chloropyridine derivatives for studies of antitumor agents and telomerase inhibitors; dihydrochromenopyrazines and chromenoquinoxalines. It is also involved in studies of its electrochemical properties using voltammetric methodologies.

The Uses of 3-HYDROXYFLAVONE

Reactant involved in:• ;Studies of photochemically-induced dioxygenase-type CO-release reactivity1• ;Phase-transfer protection and deprotection of hydroxychromones2• ;O-methylation with di-Me carbonate3Reactant involved in the synthesis of biologically active molecules including:• ;2-Chloropyridine derivatives for studies of antitumor agents and telomerase inhibitors4• ;Dihydrochromenopyrazines and chromenoquinoxalines5Involved in studies of its electrochemical properties using voltammetric methodologies6

What are the applications of Application

3-Hydroxyflavone is a reactant involved in the synthesis of biologically active molecules

Definition

ChEBI: A monohydroxyflavone that is the 3-hydroxy derivative of flavone.

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 5561, 1984 DOI: 10.1016/S0040-4039(01)81626-9

Purification Methods

Recrystallise it from MeOH (m 169.5-170o), EtOH, aqueous EtOH (m 167o) or hexane. It has also been purified by repeated sublimation under high vacuum, and dried at high vacuum pumping for at least one hour [Bruker & Kelly J Phys Chem 91 2856 1987]. [Beilstein 17 H 527, 17 I 268, 17 II 498, 17 III/IV 6428.]

Properties of 3-HYDROXYFLAVONE

Melting point: 171-172 °C (lit.)
Boiling point: 320.83°C (rough estimate)
Density  1.2653 (rough estimate)
refractive index  1.5740 (estimate)
storage temp.  Inert atmosphere,Room Temperature
solubility  DMSO: 1 mg/ml
pka 8.80±0.20(Predicted)
form  powder to crystal
color  White to Yellow to Green
Water Solubility  Insoluble in water. Soluble in N,N-DMF and ethanol.
BRN  15789
CAS DataBase Reference 577-85-5(CAS DataBase Reference)
EPA Substance Registry System 4H-1-Benzopyran-4-one, 3-hydroxy-2-phenyl- (577-85-5)

Safety information for 3-HYDROXYFLAVONE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 3-HYDROXYFLAVONE

InChIKey HVQAJTFOCKOKIN-UHFFFAOYSA-N

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