3-HYDROXYFLAVONE
Synonym(s):Flavonol
- CAS NO.:577-85-5
- Empirical Formula: C15H10O3
- Molecular Weight: 238.24
- MDL number: MFCD00006832
- EINECS: 209-416-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is 3-HYDROXYFLAVONE?
Chemical properties
yellow fluffy powder
The Uses of 3-HYDROXYFLAVONE
3-Hydroxyflavone is a reactant involved in studies of photochemically-induced dioxygenase-type CO-release reactivity; phase-transfer protection and deprotection of hydroxychromones; and O-methylation with di-Me carbonate. As a reactant it is involved in the synthesis of biologically active molecules including 2-chloropyridine derivatives for studies of antitumor agents and telomerase inhibitors; dihydrochromenopyrazines and chromenoquinoxalines. It is also involved in studies of its electrochemical properties using voltammetric methodologies.
The Uses of 3-HYDROXYFLAVONE
Reactant involved in:• ;Studies of photochemically-induced dioxygenase-type CO-release reactivity1• ;Phase-transfer protection and deprotection of hydroxychromones2• ;O-methylation with di-Me carbonate3Reactant involved in the synthesis of biologically active molecules including:• ;2-Chloropyridine derivatives for studies of antitumor agents and telomerase inhibitors4• ;Dihydrochromenopyrazines and chromenoquinoxalines5Involved in studies of its electrochemical properties using voltammetric methodologies6
What are the applications of Application
3-Hydroxyflavone is a reactant involved in the synthesis of biologically active molecules
Definition
ChEBI: A monohydroxyflavone that is the 3-hydroxy derivative of flavone.
Synthesis Reference(s)
Tetrahedron Letters, 25, p. 5561, 1984 DOI: 10.1016/S0040-4039(01)81626-9
Purification Methods
Recrystallise it from MeOH (m 169.5-170o), EtOH, aqueous EtOH (m 167o) or hexane. It has also been purified by repeated sublimation under high vacuum, and dried at high vacuum pumping for at least one hour [Bruker & Kelly J Phys Chem 91 2856 1987]. [Beilstein 17 H 527, 17 I 268, 17 II 498, 17 III/IV 6428.]
Properties of 3-HYDROXYFLAVONE
Melting point: | 171-172 °C (lit.) |
Boiling point: | 320.83°C (rough estimate) |
Density | 1.2653 (rough estimate) |
refractive index | 1.5740 (estimate) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO: 1 mg/ml |
pka | 8.80±0.20(Predicted) |
form | powder to crystal |
color | White to Yellow to Green |
Water Solubility | Insoluble in water. Soluble in N,N-DMF and ethanol. |
BRN | 15789 |
CAS DataBase Reference | 577-85-5(CAS DataBase Reference) |
EPA Substance Registry System | 4H-1-Benzopyran-4-one, 3-hydroxy-2-phenyl- (577-85-5) |
Safety information for 3-HYDROXYFLAVONE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-HYDROXYFLAVONE
InChIKey | HVQAJTFOCKOKIN-UHFFFAOYSA-N |
Abamectin manufacturer
AVIGYABIOSCIENCES PRIVATE LIMITED
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