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HomeProduct name list3-Hydroxy-4-methoxybenzyl alcohol

3-Hydroxy-4-methoxybenzyl alcohol

Synonym(s):Isovanillyl alcohol

  • CAS NO.:4383-06-6
  • Empirical Formula: C8H10O3
  • Molecular Weight: 154.16
  • MDL number: MFCD00004644
  • EINECS: 224-489-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
3-Hydroxy-4-methoxybenzyl alcohol Structural

What is 3-Hydroxy-4-methoxybenzyl alcohol?

Chemical properties

White crystalline

The Uses of 3-Hydroxy-4-methoxybenzyl alcohol

3-Hydroxy-4-methoxybenzyl alcohol was used in preparation of 2-hydroxymethyl-5-methoxy-2,5-cyclohexadiene-1,4-dione by oxidation with Fremy′s salt.

Synthesis

3-Hydroxy-4-methoxybenzyl alcohol is synthesised using isovanillin as raw material by chemical reaction. The specific synthesis steps are as follows:
In a round-bottom flask equipped with magnetic stirrer was added 15 sodium borohydride (0.2mmol; 0.01g) to the solution of 9 1 (0.2mmol; 0.03g) prepared in ethanol (1mL). The mixture was stirred at room temperature for 30min. The consumption of all starting material was detected by thin layer chromatography (TLC); the solvent was evaporated under reduced pressure. Subsequently, 10mL of saturated NaCl solution was added and then extracted with ethyl acetate (3×10mL). The organic phase was dried over anhydrous MgSO4, filtered and evaporated, providing 0.03g of colorless oil, 90% yield of 3-Hydroxy-4-methoxybenzyl alcohol.
3-Hydroxy-4-methoxybenzyl alcohol synthesis

Properties of 3-Hydroxy-4-methoxybenzyl alcohol

Melting point: 135-137 °C (lit.)
Boiling point: 315.8±27.0 °C(Predicted)
Density  1.226±0.06 g/cm3(Predicted)
storage temp.  Inert atmosphere,Room Temperature
solubility  soluble in Methanol
form  powder to crystal
pka 9.75±0.10(Predicted)
color  White to Almost white
BRN  1867860
CAS DataBase Reference 4383-06-6(CAS DataBase Reference)
NIST Chemistry Reference 3-Hydroxy-4-methoxybenzyl alcohol(4383-06-6)

Safety information for 3-Hydroxy-4-methoxybenzyl alcohol

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 3-Hydroxy-4-methoxybenzyl alcohol

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