3-Hydroxy-4-methoxybenzyl alcohol
Synonym(s):Isovanillyl alcohol
- CAS NO.:4383-06-6
- Empirical Formula: C8H10O3
- Molecular Weight: 154.16
- MDL number: MFCD00004644
- EINECS: 224-489-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-12-21 15:28:39
What is 3-Hydroxy-4-methoxybenzyl alcohol?
Chemical properties
White crystalline
The Uses of 3-Hydroxy-4-methoxybenzyl alcohol
3-Hydroxy-4-methoxybenzyl alcohol was used in preparation of 2-hydroxymethyl-5-methoxy-2,5-cyclohexadiene-1,4-dione by oxidation with Fremy′s salt.
Synthesis
3-Hydroxy-4-methoxybenzyl alcohol is synthesised using isovanillin as raw material by chemical reaction. The specific synthesis steps are as follows:
In a round-bottom flask equipped with magnetic stirrer was added 15 sodium borohydride (0.2mmol; 0.01g) to the solution of 9 1 (0.2mmol; 0.03g) prepared in ethanol (1mL). The mixture was stirred at room temperature for 30min. The consumption of all starting material was detected by thin layer chromatography (TLC); the solvent was evaporated under reduced pressure. Subsequently, 10mL of saturated NaCl solution was added and then extracted with ethyl acetate (3×10mL). The organic phase was dried over anhydrous MgSO4, filtered and evaporated, providing 0.03g of colorless oil, 90% yield of 3-Hydroxy-4-methoxybenzyl alcohol.
Properties of 3-Hydroxy-4-methoxybenzyl alcohol
Melting point: | 135-137 °C (lit.) |
Boiling point: | 315.8±27.0 °C(Predicted) |
Density | 1.226±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | soluble in Methanol |
form | powder to crystal |
pka | 9.75±0.10(Predicted) |
color | White to Almost white |
BRN | 1867860 |
CAS DataBase Reference | 4383-06-6(CAS DataBase Reference) |
NIST Chemistry Reference | 3-Hydroxy-4-methoxybenzyl alcohol(4383-06-6) |
Safety information for 3-Hydroxy-4-methoxybenzyl alcohol
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 3-Hydroxy-4-methoxybenzyl alcohol
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