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HomeProduct name list3'-DEPHOSPHOCOENZYME A

3'-DEPHOSPHOCOENZYME A

Synonym(s):3′-Desphosphocoenzyme A;dpCoA

  • CAS NO.:3633-59-8
  • Empirical Formula: C21H35N7O13P2S
  • Molecular Weight: 687.55
  • MDL number: MFCD00057010
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-25 23:13:37
3'-DEPHOSPHOCOENZYME A Structural

What is 3'-DEPHOSPHOCOENZYME A?

Description

3''-Dephosphocoenzyme A is an intermediate in the biosynthesis of coenzyme A (CoA; Item Nos. 16147 | 21499 | 21722) from pantothenic acid (vitamin B5; ). It is phosphorylated by CoA synthase in humans to form CoA. 3''-Dephosphocoenzyme A can be used as a transcription initiator in the synthesis of CoA-RNA by in vitro transcription.

The Uses of 3'-DEPHOSPHOCOENZYME A

Dephosphocoenzyme A is the direct precursor of coenzyme A. It is used for the synthesis of coenzyme A by bifunctional CoA Synthase (CoASy, 4′-phosphopantetheine adenylyltransferase/dephospho-CoA kinase) which performs the transfer of the γ-phosphate of ATP to dephosphocoenzyme A.

What are the applications of Application

3′-Dephosphocoenzyme A is A chemical reagent that is the direct precursor of coenzyme A. It is used for the synthesis of coenzyme A by bifunctional CoA Synthase.

Definition

ChEBI: An adenosine 5'-phosphate that is coenzyme A in which the phosphate group at position 3' has been replaced by a hydrogen atom. It is an intermediate metabolite in pantothenate and CoA biosynthesis

Biochem/physiol Actions

3′-Dephosphocoenzyme A (DepCoA), also called desphosphoCoA (dpCoA), is synthesized from 4-phosphopantetheine by the enzyme phosphopanthetheine adenylyltransferase. It is an intermediate in coenzyme A biosynthetic pathway. In the presence of dephospho-CoA kinase (CoaE), dephosphocoenzyme A is converted to coenzyme A. 3′-Dephosphocoenzyme shares adenosine-diphosphate substructure as like the purines and is a non-canonical nucleotide and is an initiator of transcription initiation. It is routinely used in in vitro transcription studies to initiate RNA synthesis.

Properties of 3'-DEPHOSPHOCOENZYME A

Density  1.85±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  Water: 50 mg/ml
form  A crystalline solid
pka 1.16±0.50(Predicted)

Safety information for 3'-DEPHOSPHOCOENZYME A

Computed Descriptors for 3'-DEPHOSPHOCOENZYME A

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