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HomeProduct name list3-DEAZAADENOSINE

3-DEAZAADENOSINE

Synonym(s):4-Amino-1-(β-D-ribofuranosyl)-1H-imidazo(4,5)-pyridine

3-DEAZAADENOSINE Structural

What is 3-DEAZAADENOSINE?

Description

3-Deazaadenosine (3-DZA) is an inhibitor of SAH (Sadenosylhomocysteine) hydrolase (Ki = 3.9 μM). It has antiinflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling. 3-DZA also has anti-viral and anti-bacterial activities.

Chemical properties

Bright Yellow Solid

The Uses of 3-DEAZAADENOSINE

Possesses antiviral activity. It is an inhibitor of leukocyte adhesion to TNF-treated endothelial cells

The Uses of 3-DEAZAADENOSINE

Possesses antiviral activity. It is an inhibitor of leukocyte adhesion to TNF-treated endothelial cells.

What are the applications of Application

3-Deazaadenosine is an inhibitor of leukocyte adhesion to TNF-treated endothelial cells

Biochem/physiol Actions

Possesses antiviral activity inhibitor of leukocyte adhesion to TNF-treated endothelial cells.

in vitro

3-deazaadenosine showed inhibitory values against the ebo-z viruses, ebo, and marburg virus in various cell lines of primate (sw13, vero 76, frhl, llc-mk2, mrc-5, vero e6) and mouse (balb/3t3 clone a31) origin. 3-deazaadenosine at 2 μg/ml could reduce viral replication by 3 logs in a dose-dependent manner. however, there was no further inhibition even with a 100-fold increase in concentration [1].

in vivo

in vehicle control group, adult balb/c mice lethally infected with mouse-adapted ebola virus die 5-7 days after infection. in contrast, 3-deazaadenosine treatment initiated on day 0 or 1 led to a dose-dependent protection, with mortality completely prevented at doses around 0.7 mg/kg every 8 h. moreover, there was significant protection when 3-deazaadenosine treatment was begun on day 2, at which time, the spleen had an average titer of 2 × 106 pfu/g and the liver had 3 × 105 pfu/g virus. treatment with 3-aeazaadenosine at 2.2 mg/kg initiated on day 3 resulted in 40% survival [1].

References

[1] huggins, z. x. zhang and m. bray. antiretroviral drug therapy of filovirus infections: s-adenosylhomocysteine hydrolase inhibitors inhibit ebola virus in vitro and in a lethal mouse model. journal of infectious diseases 179 (1), s240-s247 (1999).

Properties of 3-DEAZAADENOSINE

Melting point: 228-229°C
Boiling point: 665.7±65.0 °C(Predicted)
Density  1.90±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.  Keep in dark place,Inert atmosphere,2-8°C
solubility  H2O: 10 mg/mL with heating to 60 °C
form  Solid
pka 13.24±0.70(Predicted)
color  White to Off-White

Safety information for 3-DEAZAADENOSINE

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H331:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P311:Call a POISON CENTER or doctor/physician.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 3-DEAZAADENOSINE

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