3-DEAZAADENOSINE
Synonym(s):4-Amino-1-(β-D -ribofuranosyl)-1H-imidazo(4,5)-pyridine
- CAS NO.:6736-58-9
- Empirical Formula: C11H14N4O4
- Molecular Weight: 266.25
- MDL number: MFCD00153951
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:06
What is 3-DEAZAADENOSINE?
Description
3-Deazaadenosine (3-DZA) is an inhibitor of SAH (Sadenosylhomocysteine) hydrolase (Ki = 3.9 μM). It has antiinflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling. 3-DZA also has anti-viral and anti-bacterial activities.
Chemical properties
Bright Yellow Solid
The Uses of 3-DEAZAADENOSINE
Possesses antiviral activity. It is an inhibitor of leukocyte adhesion to TNF-treated endothelial cells
The Uses of 3-DEAZAADENOSINE
Possesses antiviral activity. It is an inhibitor of leukocyte adhesion to TNF-treated endothelial cells.
What are the applications of Application
3-Deazaadenosine is an inhibitor of leukocyte adhesion to TNF-treated endothelial cells
Biochem/physiol Actions
Possesses antiviral activity inhibitor of leukocyte adhesion to TNF-treated endothelial cells.
in vitro
3-deazaadenosine showed inhibitory values against the ebo-z viruses, ebo, and marburg virus in various cell lines of primate (sw13, vero 76, frhl, llc-mk2, mrc-5, vero e6) and mouse (balb/3t3 clone a31) origin. 3-deazaadenosine at 2 μg/ml could reduce viral replication by 3 logs in a dose-dependent manner. however, there was no further inhibition even with a 100-fold increase in concentration [1].
in vivo
in vehicle control group, adult balb/c mice lethally infected with mouse-adapted ebola virus die 5-7 days after infection. in contrast, 3-deazaadenosine treatment initiated on day 0 or 1 led to a dose-dependent protection, with mortality completely prevented at doses around 0.7 mg/kg every 8 h. moreover, there was significant protection when 3-deazaadenosine treatment was begun on day 2, at which time, the spleen had an average titer of 2 × 106 pfu/g and the liver had 3 × 105 pfu/g virus. treatment with 3-aeazaadenosine at 2.2 mg/kg initiated on day 3 resulted in 40% survival [1].
References
[1] huggins, z. x. zhang and m. bray. antiretroviral drug therapy of filovirus infections: s-adenosylhomocysteine hydrolase inhibitors inhibit ebola virus in vitro and in a lethal mouse model. journal of infectious diseases 179 (1), s240-s247 (1999).
Properties of 3-DEAZAADENOSINE
Melting point: | 228-229°C |
Boiling point: | 665.7±65.0 °C(Predicted) |
Density | 1.90±0.1 g/cm3 (20 ºC 760 Torr) |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | H2O: 10 mg/mL with heating to 60 °C |
form | Solid |
pka | 13.24±0.70(Predicted) |
color | White to Off-White |
Safety information for 3-DEAZAADENOSINE
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-DEAZAADENOSINE
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