3-Chloro-2-butanone

Synonym(s):Chloro-MEK

CAS NO.：4091-39-8
Empirical Formula: C4H7ClO
Molecular Weight: 106.55
MDL number: MFCD00000865
EINECS: 223-834-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-01 17:24:36

What is 3-Chloro-2-butanone?

Chemical properties

CLEAR YELLOW TO BROWNISH LIQUID

The Uses of 3-Chloro-2-butanone

3-Chloro-2-butanone was used in production of chiral alcohols from acetophenone derivatives, β-ketoesters and N-Boc-3-pyrrolidinone by recombinant E. coli cells. It was used in the synthesis of carbene precursor, 3-aryl-4,5-dimethylthiazolium chloride.

The Uses of 3-Chloro-2-butanone

3-Chloro-2-butanone was used to study various carbonylic compounds as substrates for 4-hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 5274, 1955 DOI: 10.1021/ja01625a016

General Description

3-Chloro-2-butanone reacts with 1,4-dianion of acetophenone N-ethoxycarbonylhydrazone to yield pyrazoline derivatives.

Properties of 3-Chloro-2-butanone

Melting point:	<-60°C
Boiling point:	114-117 °C (lit.)
Density	1.055 g/mL at 25 °C (lit.)
refractive index	n20/D 1.421(lit.)
Flash point:	70 °F
storage temp.	Flammables area
solubility	30g/l
form	clear liquid
Specific Gravity	1.058 (20/4℃)
color	Light orange to Yellow to Green
PH	2.4 (25g/l, H2O, 20℃)
explosive limit	2.3%(V)
Water Solubility	3 g/100 mL
BRN	385637
CAS DataBase Reference	4091-39-8(CAS DataBase Reference)
NIST Chemistry Reference	2-Butanone, 3-chloro-(4091-39-8)
EPA Substance Registry System	2-Butanone, 3-chloro- (4091-39-8)

Safety information for 3-Chloro-2-butanone

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H302:Acute toxicity,oral
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.