3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE
Synonym(s):3-(Trimethylsilyl)propargyl bromide;3-Bromo-1-(trimethylsilyl)-1-propyne
- CAS NO.：38002-45-8
- Empirical Formula: C6H11BrSi
- Molecular Weight: 191.14
- MDL number: MFCD00134460
- EINECS: 609-506-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-09 16:05:57
What is 3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE?
Chemical properties
Clear colorless to pale yellow liquid
The Uses of 3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE
3-Bromo-1-(trimethylsilyl)-1-propyne may be used in the preparation of tetrahydroisoquinoline-3-carboxylic acid derivatives. It may be used as reagent for the alkylation of dianion of β-keto esters at γ-carbon. It may be employed in the preparation of terminal conjugated enynes and allenic alcohols.
General Description
3-Bromo-1-(trimethylsilyl)-1-propyne is reported as a propargylating agent. Selective reaction of 3-bromo-1-(trimethylsilyl)-1-propyne with α-keto ester using indium metal has been studied.
Properties of 3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE
| Melting point: | <0°C |
| Boiling point: | 44-45 °C2 mm Hg(lit.) |
| Density | 1.17 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 145 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Oil |
| color | Colourless to Pale Yellow |
| Specific Gravity | 1.351 |
| Water Solubility | Immiscible with water. |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| BRN | 2037650 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 38002-45-8(CAS DataBase Reference) |
Safety information for 3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE
| InChIKey | GAPRPFRDVCCCHR-UHFFFAOYSA-N |
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