3-(Aminomethyl)pyridine
Synonym(s):3-(Aminomethyl)pyridine
- CAS NO.:3731-52-0
- Empirical Formula: C6H8N2
- Molecular Weight: 108.14
- MDL number: MFCD00006412
- EINECS: 223-091-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-08 09:11:11
What is 3-(Aminomethyl)pyridine?
Chemical properties
CLEAR COLOURLESS TO SLIGHLY YELLOW LIQUID
The Uses of 3-(Aminomethyl)pyridine
rubefacient
The Uses of 3-(Aminomethyl)pyridine
It finds its application as a rubefacient.
What are the applications of Application
3-(Aminomethyl)pyridine can be used to prepare metal complexes. A number of complexes of cobalt(II), nickel(II) and copper(II) thiocyanates, chlorides and bromides with 3-pyridine amine were prepared and the stereochemical configurations of these complexes were deduced using spectroscopy and magnetism, and the decomposition of the complexes was studied by thermogravimetry and differential thermal analysis[2].
Synthesis
Synthesis of 3-(aminomethyl)pyridine by traceless C3-selective umpolung of 1-amidopyridin-1-ium salts?. A natural product inspired rapid access of 3-(aminomethyl)pyridine by one-pot reaction of 1-amidopyridin-1-ium salt with aminal followed by reductive cleavage of the N–N bond is developed. This C3-selective formal C–H activation of pyridine features a traceless umpolung of the 1-amidopyridin-1-ium salt toward a Mannich type C–C bond formation of the in situ generated 1-amido-2-dialkylamino-1,2-dihydropyridine intermediate[1].
References
[1] TANG P, XIAO D, WANG B. Synthesis of 3-(aminomethyl)pyridine by traceless C3-selective umpolung of 1-amidopyridin-1-ium salts?[J]. Chemical Communications, 2017. DOI:10.1039/C6CC09582H.
[2] J. R. ALLAN M. J P A D Paton. The preparation, characterisation and thermal analysis studies on complexes of cobalt(II), nickel(II), and copper(II) with 3-picolylamine[J]. Journal of Thermal Analysis and Calorimetry, 1985. DOI:10.1007/BF01913603.
Properties of 3-(Aminomethyl)pyridine
Melting point: | −21 °C(lit.) |
Boiling point: | 73-74 °C1 mm Hg(lit.) |
Density | 1.062 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | 213 °F |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | soluble in Chloroform, Ethyl Acetate, Methanol |
pka | 8.34±0.29(Predicted) |
form | clear liquid |
color | Colorless to Light yellow |
PH | 11-12 (100g/l, H2O, 20℃) |
Water Solubility | FREELY SOLUBLE |
Sensitive | Air Sensitive |
BRN | 108056 |
CAS DataBase Reference | 3731-52-0(CAS DataBase Reference) |
NIST Chemistry Reference | Picolamine(3731-52-0) |
EPA Substance Registry System | 3-Pyridinemethanamine (3731-52-0) |
Safety information for 3-(Aminomethyl)pyridine
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H290:Corrosive to Metals H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P234:Keep only in original container. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-(Aminomethyl)pyridine
Abamectin manufacturer
Vardhaman P Golechha
JSK Chemicals
ALS INDIA LIFE SCIENCES
Madin Life Sciences Pvt Ltd
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