3-Amino-9-ethylcarbazole
Synonym(s):3-Amino-9-ethylcarbazole, 3AC;9-Ethylcarbazol-3-amine;AEC
- CAS NO.:132-32-1
- Empirical Formula: C14H14N2
- Molecular Weight: 210.27
- MDL number: MFCD00004964
- EINECS: 205-057-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-10 07:27:02
What is 3-Amino-9-ethylcarbazole?
Chemical properties
3-Amino-9-ethylcarbazole is a brownish or tannish powder and chunks. It is utilized for producing dyes and pigments, as well as serving as an indicator for peroxidase in cells and a biological stain.
The Uses of 3-Amino-9-ethylcarbazole
3-Amino-9-ethylcarbazole (AEC) has been used as a chromogen in immunohistochemistry to visualize the cells. It has also been used as a substrate in enzyme-linked immune absorbent spot (ELISpot).
What are the applications of Application
AEC, 50X is In the presence of horseradish peroxidase (HRP), produces a water-insoluble red oxidation product
What are the applications of Application
AEC Substrate Buffer, 10X is a 10X buffer diluent for use with AEC. For use in HRP-based detection systems
Definition
ChEBI: 3-Amino-9-ethylcarbazole is a hydrochloride salt and free amine solid compound. It has been used to visualize the bound primary antibody by using a streptavidin method. It has also been used in visualizing tissue sections from tumour samples.
Preparation
Prepared by reducing 3-nitro-N-ethylcarbazole with sodium sulfide.
General Description
Tan powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
3-Amino-9-ethylcarbazole neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides.
Hazard
Questionable carcinogen; poison.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 3-Amino-9-ethylcarbazole emits toxic fumes.
Fire Hazard
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Safety Profile
Suspected carcinogen with experimental carcinogenic data. Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx,.
Potential Exposure
Plant workers engaged in the manufacture of this compound and its use in pigment manufacture. Laboratory workers using this material in colorimetric enzyme assays and as a biological stain
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Incompatibilities
3-Amino-9-ethylcarbazole neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides.
Waste Disposal
Incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions.
Properties of 3-Amino-9-ethylcarbazole
Melting point: | 85-88 °C(lit.) |
Boiling point: | 355C |
Density | 1,15g/cm |
refractive index | 1.6180 (estimate) |
storage temp. | 2-8°C |
solubility | Chloroform (Sparingly), Methanol (Slightly) |
form | tablet |
pka | 4.99±0.30(Predicted) |
color | Brown to Very Dark Brown |
BRN | 174969 |
CAS DataBase Reference | 132-32-1(CAS DataBase Reference) |
NIST Chemistry Reference | 9H-carbazol-3-amine, 9-ethyl-(132-32-1) |
EPA Substance Registry System | 3-Amino-9-ethylcarbazole (132-32-1) |
Safety information for 3-Amino-9-ethylcarbazole
Signal word | Danger |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H350:Carcinogenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for 3-Amino-9-ethylcarbazole
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