3-Amino-4-methoxybenzanilide
- CAS NO.:120-35-4
- Empirical Formula: C14H14N2O2
- Molecular Weight: 242.27
- MDL number: MFCD00017166
- EINECS: 204-388-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-26 15:15:06
What is 3-Amino-4-methoxybenzanilide?
Chemical properties
Gray powder.
The Uses of 3-Amino-4-methoxybenzanilide
3-Amino-4-methoxybenzanilide is used in preparation method of Cyanate resin-based near-zero expansion composite material truss rod.
The Uses of 3-Amino-4-methoxybenzanilide
Dyes, pharmaceuticals, and other organic chemicals.
Synthesis
3-Amino-4-methoxybenzanilide is prepared by the reaction of 3-amino-4-methoxybenzoic acid and aniline. The steps are as follows:
A total of 0.17 mL (0.18 mmol) of DIC and 0.24 g (0.18 mmol) of HOBt were added to a dichloromethane solution of 0.20 g (0.12 mmol) of 1 at room temperature, and the reaction mixture was stirred for 0.5 h.
Then, 0.13 mL (0.14 mmol) of aniline was added to the mixture.
After approximately 3 h, 0.5 N NaOH was added to the solution.
The lower layer was isolated, and 0.5 N HCl was added until the aqueous solution was neutral.
The dichloromethane layer was washed three times with 10 mL of water, and then MgSO4 was added.
After 2 h, the solution was filtered, and the solvent was removed.
The residue was purified by column chromatography on silica gel (eluent: petroleum ether:ethyl acetate = 3:1) to yield the desired 3-Amino-4-methoxybenzanilide as a white solid (yield: 76%). Mp: 197-198 °C. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 9.92 (1H, s, NH), 7.74 (2H, d, J = 9.0 Hz, PhH), 7.32 (2H, m, PhH), 7.21 (2H, d, J = 8.0 Hz, PhH), 7.06 (1H, m, PhH), 6.88 (1H, d, J = 8.0 Hz, PhH), 4.90 (2H, br s, NH2), 3.83 (3H, s, OCH3). ESI-MS (m/z): 243 (M + H)+.
Properties of 3-Amino-4-methoxybenzanilide
Melting point: | 154-156°C |
Boiling point: | 385.1°C (rough estimate) |
Density | 1.1338 (rough estimate) |
vapor pressure | 0-0Pa at 25℃ |
refractive index | 1.6419 (estimate) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 13.44±0.70(Predicted) |
form | Solid |
color | White to Off-White |
CAS DataBase Reference | 120-35-4(CAS DataBase Reference) |
EPA Substance Registry System | Benzamide, 3-amino-4-methoxy-N-phenyl- (120-35-4) |
Safety information for 3-Amino-4-methoxybenzanilide
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-Amino-4-methoxybenzanilide
Abamectin manufacturer
Amogh Chemicals Pvt Ltd
Ashu Organics Pvt Ltd (Rupa Organics Pvt Ltd)
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