3-Amino-1H-pyrazole-4-carboxamide

CAS NO.：5334-31-6
Empirical Formula: C4H6N4O
Molecular Weight: 126.12
MDL number: MFCD00082808
EINECS: 226-252-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 3-Amino-1H-pyrazole-4-carboxamide?

The Uses of 3-Amino-1H-pyrazole-4-carboxamide

5-Amino-4-pyrazolecarboxamide is used in the synthesis of 4H-3,1-Benzothiazinone analogs as antiproliferative agents against human cancer cell lines. Also, it is an intermediate used in the synthesis of 3-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide (T767570), which is an impurity of Allopurinol (A547300), which is a xanthine oxidase inhibitor; decreases uric acid production. Used in treatment of hyperuricemia and chronic gout. Antiurolithic.

Properties of 3-Amino-1H-pyrazole-4-carboxamide

Melting point:	187-189 °C(Solv: water (7732-18-5))
Boiling point:	454.3±25.0 °C(Predicted)
Density	1.538±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	DMSO (Slightly), Methanol (Very Slightly)
form	Solid
pka	13.26±0.50(Predicted)
color	Off-White to Pale Beige

Safety information for 3-Amino-1H-pyrazole-4-carboxamide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.