3-(2-Furyl)acrylic acid

Synonym(s):Furan-2-acrylic acid;Furfurylideneacetic acid

CAS NO.：539-47-9
Empirical Formula: C7H6O3
Molecular Weight: 138.12
MDL number: MFCD00003257
EINECS: 208-718-8
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-25 18:01:20

What is 3-(2-Furyl)acrylic acid?

Chemical properties

white to light yellow crystal powde

The Uses of 3-(2-Furyl)acrylic acid

3-(2-Furyl)acrylic acid is derivatives used in perfumes.

The Uses of 3-(2-Furyl)acrylic acid

3-(2-Furyl)acrylic acid is a reactant used in the preparation of heteroaryl-substituted bis-trifluoromethyl carbinols and trifluoroacetophenone derivatives malonyl-CoA decarboxylase (MCD) inhibitors.

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 3425, 1956 DOI: 10.1021/ja01595a044
Organic Syntheses, Coll. Vol. 3, p. 426, 1955

Purification Methods

Crystallise the cis-isomer from *C6H6 and the trans-isomer from H2O, *C6H6 or pet ether (b 80-100o)(charcoal). [Beilstein 18 H 301, 18 III/IV 4143, 18/6 V 306.]

Properties of 3-(2-Furyl)acrylic acid

Melting point:	139-141 °C (lit.)
Boiling point:	286 °C (lit.)
Density	1.2667 (rough estimate)
refractive index	1.4600 (estimate)
Flash point:	286°C
storage temp.	Store below +30°C.
solubility	Soluble in dichloromethane and diethyl ether.
form	Solid
pka	4.39±0.10(Predicted)
color	Pale Beige
Water Solubility	2g/L(20 ºC)
Merck	14,4297
BRN	81046
Stability:	Light Sensitive
CAS DataBase Reference	539-47-9(CAS DataBase Reference)
NIST Chemistry Reference	2-Propenoic acid, 3-(2-furanyl)-(539-47-9)
EPA Substance Registry System	2-Propenoic acid, 3-(2-furanyl)- (539-47-9)

Safety information for 3-(2-Furyl)acrylic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.