(2S,3R)-(+)-4-DIMETHYLAMINO-1,2-DIPHENYL-3-METHYL-2-BUTANOL
Synonym(s):(2S,3R)-(+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-butanol;(2S,3R)-(+)-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol;Dextrocarbinol base
- CAS NO.：38345-66-3
- Empirical Formula: C19H25NO
- Molecular Weight: 283.41
- MDL number: MFCD00066214
- EINECS: 253-893-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 13:37:16
What is (2S,3R)-(+)-4-DIMETHYLAMINO-1,2-DIPHENYL-3-METHYL-2-BUTANOL?
The Uses of (2S,3R)-(+)-4-DIMETHYLAMINO-1,2-DIPHENYL-3-METHYL-2-BUTANOL
Reducing reagent in organic synthesis.
Purification Methods
Purify the hydrochloride by dissolving 1.5g in 13.5 mL of 5N HCl, heat to boiling and evaporate in a vacuum. Recrystallise the hydrochloride three times from MeOH/EtOAc giving m 189-190o, []D -33.7o (c 1, H2O) {enantiomer has +34.2o}. The hydrochloride in the minimum volume of water is basified with aqueous 5N NaOH and extracted with Et2O. The extract is dried (K2CO3) and evaporated, leaving a residue which is stored in a desiccator over solid KOH as a low melting solid. It can be recovered using these procedures from asymmetric reductions with LAH, and re-used. [Pohland & Sullivan J Am Chem Soc 77 3400 1955, Sullivan et al. J Org Chem 28 2483 1963, Beilstein 13 IV 2221.]
Properties of (2S,3R)-(+)-4-DIMETHYLAMINO-1,2-DIPHENYL-3-METHYL-2-BUTANOL
| Melting point: | 54-56 °C(lit.) |
| Boiling point: | bp0.1 mm 138-139° |
| alpha | 21 +8.2° (c = 10 in ethanol) |
| Flash point: | >230 °F |
| optical activity | [α]21/D +8.2°, c = 10 in ethanol |
| Merck | 13,2070 |
| BRN | 2384178 |
| EPA Substance Registry System | Benzeneethanol, ?-[(1R)-2-(dimethylamino)-1-methylethyl]-?-phenyl-, (?S)- (38345-66-3) |
Safety information for (2S,3R)-(+)-4-DIMETHYLAMINO-1,2-DIPHENYL-3-METHYL-2-BUTANOL
Computed Descriptors for (2S,3R)-(+)-4-DIMETHYLAMINO-1,2-DIPHENYL-3-METHYL-2-BUTANOL
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