2,6,6-TRIMETHYL-1-CYCLOHEXENE-1-ACETALDEHYDE

Synonym(s):β-Homocyclocitral

2,6,6-Trimethyl-1-cyclohexene-1-acetaldehyde can be used as a starting material to prepare:

(±)-Aeginetolide by oxidation in the presence of meta-chloroperoxybenzoic acid (m-CPBA).
(±)-Dihydroactinidiolide (a C₁₁-terpenic lactone) via dehydration of key intermediate aeginetolide.

It can also be used as a key intermediate to synthesize drimane-related sesquiterpenes and substituted retinoic acid analogs.

ChEBI: 2,6,6-Trimethyl-1-cyclohexen-1-acetaldehyde is an aldehyde.

Taste characteristics at 15 ppm: cooling, woody, oily, soapy, citrus with a berry, orris-like nuance.

Boiling point:	58-59 °C/0.4 mmHg (lit.)
Density	0.941 g/mL at 25 °C (lit.)
refractive index	n20/D 1.485(lit.)
FEMA	3474 \| 2,6,6-TRIMETHYL-1-CYCLOHEXEN-1-ACETALDEHYDE
Flash point:	191 °F
storage temp.	2-8°C
Odor	at 10.00 % in dipropylene glycol. camphoreous cooling woody medicinal oily berry orris soapy
JECFA Number	978
EPA Substance Registry System	1-Cyclohexene-1-acetaldehyde, 2,6,6-trimethyl- (472-66-2)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.