2,6-Dioxopiperidine-3-ammonium chloride

CAS NO.：24666-56-6
Empirical Formula: C5H9ClN2O2
Molecular Weight: 164.59016
MDL number: MFCD11042437
EINECS: 807-866-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-17 21:30:02

What is 2,6-Dioxopiperidine-3-ammonium chloride?

Chemical properties

White crystal

Description

2,6-Dioxopiperidine-3-ammonium chloride is a reagent for preparing lenalidomide that can induce ubiquitination and degradation of CK1&alpha. It can also be used to prepare phthalimide conjugates that can promote ligand-dependent target protein degradation. Moreover, it is also a metabolite of thalidomide (T338850) that inhibits FGF-induced angiogenesis.

The Uses of 2,6-Dioxopiperidine-3-ammonium chloride

2,6-Dioxopiperidine-3-ammonium chloride can be used as an important intermediate of antineoplastic drug lenalidomide.

Properties of 2,6-Dioxopiperidine-3-ammonium chloride

Melting point:	120 °C (approx)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly, Heated), Methanol (Sparingly, Sonicated)
color	White

Safety information for 2,6-Dioxopiperidine-3-ammonium chloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection.