2,6-Difluoroaniline
- CAS NO.:5509-65-9
- Empirical Formula: C6H5F2N
- Molecular Weight: 129.11
- MDL number: MFCD00007655
- EINECS: 226-853-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-14 11:55:41
What is 2,6-Difluoroaniline?
Chemical properties
clear yellow to brown liquid
The Uses of 2,6-Difluoroaniline
2,6-Difluoroaniline is an important chemical in the sythesis technology for high-efficiency insecticide.
The Uses of 2,6-Difluoroaniline
2,6-Difluoroaniline was used in the synthesis of:
- N-2,6-difluorophenyl-5-methoxy-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide, herbicidal compound
- series of 2,6,9-trisubstituted purine inhibitors of p38α kinase
- substituted phenylthiomorpholine dioxide, an active pharmaceutical intermediate
The Uses of 2,6-Difluoroaniline
2,6-Difluoroaniline and several related primary amines are oxidized in chloroform by peroxybenzoic acid to the corresponding nitroso compounds. For example, treatment of 2,6-difluoroaniline with sodium azide can obtain 4-fluoro-2,1,3-benzoxadiazole, and the product is nitrified to obtain 7-nitro derivatives[1]. 2,6-Difluoroaniline is an important raw material and intermediate in organic synthesis, medicine, pesticides, dyes and other fields.
References
[1] Nunno L, et al. Oxidation of substituted anilines to nitroso-compounds. J. Chem. Soc. C, 1970; 9: 1433-1434.
Properties of 2,6-Difluoroaniline
Boiling point: | 51-52 °C/15 mmHg (lit.) |
Density | 1.199 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | 110 °F |
storage temp. | Keep in dark place,Sealed in dry,2-8°C |
solubility | Chloroform, Ethyl Acetate (Slightly) |
form | Liquid |
pka | 1.81±0.10(Predicted) |
Specific Gravity | 1.28 |
color | Clear yellow to brown |
Water Solubility | Slightly soluble in water. |
BRN | 2802697 |
Stability: | Hygroscopic |
CAS DataBase Reference | 5509-65-9(CAS DataBase Reference) |
NIST Chemistry Reference | 2,6-Difluoroaniline(5509-65-9) |
EPA Substance Registry System | 2,6-Difluoroaniline (5509-65-9) |
Safety information for 2,6-Difluoroaniline
Signal word | Warning |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H226:Flammable liquids H317:Sensitisation, Skin |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
Computed Descriptors for 2,6-Difluoroaniline
InChIKey | ODUZJBKKYBQIBX-UHFFFAOYSA-N |
Abamectin manufacturer
SNECOFRi PVT LTD
Aarti Industries Limited (AIL)
Krishna Solvechem Ltd.
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