2,6-Dichlorobenzyl bromide

Synonym(s):α-Bromo-2,6-dichlorotoluene;1-Bromomethyl-2,6-dichlorobenzene

CAS NO.：20443-98-5
Empirical Formula: C7H5BrCl2
Molecular Weight: 239.92
MDL number: MFCD00000577
EINECS: 243-827-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-03-27 14:23:05

What is 2,6-Dichlorobenzyl bromide?

Chemical properties

White solid

The Uses of 2,6-Dichlorobenzyl bromide

2,6-Dichlorobenzyl Bromide is used in the preparation of potent epoxide hydrolase inhibitors. Has shown thus far to relieve hypotension in lipopolysaccharide deficient murine models. As well they have been used in the synthesis of anti-HIV drugs based on diaryltriazine (DATA) analogues.

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 707, 1988 DOI: 10.1016/S0040-4039(00)80190-2

Properties of 2,6-Dichlorobenzyl bromide

Melting point:	54-56 °C(lit.)
Boiling point:	>110°C
Density	1.5832 (rough estimate)
refractive index	1.5700 (estimate)
Flash point:	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	methanol: 0.1 g/mL, clear
form	Crystals or Crystalline Powder
color	Colorless to white
BRN	637351
CAS DataBase Reference	20443-98-5(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 2-(bromomethyl)-1,3-dichloro-(20443-98-5)

Safety information for 2,6-Dichlorobenzyl bromide

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H314:Skin corrosion/irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.