2,6-Dichlorobenzoyl chloride
- CAS NO.：4659-45-4
- Empirical Formula: C7H3Cl3O
- Molecular Weight: 209.46
- MDL number: MFCD00000662
- EINECS: 225-102-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-31 14:34:42
What is 2,6-Dichlorobenzoyl chloride?
Chemical properties
Clear slightly yellow liquid
The Uses of 2,6-Dichlorobenzoyl chloride
2,6-Dichlorobenzoyl chloride acts as an important intermediate in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. It is employed in the substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases. It is also used in the preparation of 1-acyliridoles and (-)-aspicilin. In addition to this, it undergoes esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene.
The Uses of 2,6-Dichlorobenzoyl chloride
2,6-Dichlorobenzoyl chloride was used:
- in substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases
- in the synthesis of 1-acyliridoles
- in enantiocontrolled total synthesis of (-)-aspicilin
General Description
2,6-Dichlorobenzoyl chloride participates in esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene.
Purification Methods
Reflux the acid chloride for 2hours with excess of acetyl chloride (3 volumes), distil off AcCl followed by the benzoyl chloride. Store it away from moisture. It is an IRRITANT.[Beilstein 9 III 1377.]
Properties of 2,6-Dichlorobenzoyl chloride
| Melting point: | 15-17 °C |
| Boiling point: | 142-143 °C/21 mmHg (lit.) |
| Density | 1.462 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Inert atmosphere,2-8°C |
| form | Liquid |
| color | Clear colorless to light yellow or light pink |
| Water Solubility | Miscible with alcohol, ether and acetone. Slightly miscible with heptane. Immiscible with water. |
| Sensitive | Moisture Sensitive |
| BRN | 639531 |
| CAS DataBase Reference | 4659-45-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 2,6-Dichlorobenzoyl chloride(4659-45-4) |
Safety information for 2,6-Dichlorobenzoyl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2,6-Dichlorobenzoyl chloride
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product: 4659-45-4 2,6-Dichlorobenzoyl Chloride 99%
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