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HomeProduct name list2,6-Dichlorobenzoyl chloride

2,6-Dichlorobenzoyl chloride

  • CAS NO.:4659-45-4
  • Empirical Formula: C7H3Cl3O
  • Molecular Weight: 209.46
  • MDL number: MFCD00000662
  • EINECS: 225-102-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-31 14:34:42
2,6-Dichlorobenzoyl chloride Structural

What is 2,6-Dichlorobenzoyl chloride?

Chemical properties

Clear slightly yellow liquid

The Uses of 2,6-Dichlorobenzoyl chloride

2,6-Dichlorobenzoyl chloride acts as an important intermediate in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. It is employed in the substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases. It is also used in the preparation of 1-acyliridoles and (-)-aspicilin. In addition to this, it undergoes esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene.

The Uses of 2,6-Dichlorobenzoyl chloride

2,6-Dichlorobenzoyl chloride was used:

  • in substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases
  • in the synthesis of 1-acyliridoles
  • in enantiocontrolled total synthesis of (-)-aspicilin

General Description

2,6-Dichlorobenzoyl chloride participates in esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene.

Purification Methods

Reflux the acid chloride for 2hours with excess of acetyl chloride (3 volumes), distil off AcCl followed by the benzoyl chloride. Store it away from moisture. It is an IRRITANT.[Beilstein 9 III 1377.]

Properties of 2,6-Dichlorobenzoyl chloride

Melting point: 15-17 °C
Boiling point: 142-143 °C/21 mmHg (lit.)
Density  1.462 g/mL at 25 °C (lit.)
refractive index  n20/D 1.560(lit.)
Flash point: >230 °F
storage temp.  Inert atmosphere,2-8°C
form  Liquid
color  Clear colorless to light yellow or light pink
Water Solubility  Miscible with alcohol, ether and acetone. Slightly miscible with heptane. Immiscible with water.
Sensitive  Moisture Sensitive
BRN  639531
CAS DataBase Reference 4659-45-4(CAS DataBase Reference)
NIST Chemistry Reference 2,6-Dichlorobenzoyl chloride(4659-45-4)

Safety information for 2,6-Dichlorobenzoyl chloride

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H314:Skin corrosion/irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P363:Wash contaminated clothing before reuse.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 2,6-Dichlorobenzoyl chloride

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