3,5-Dichlorobenzoyl chloride

CAS NO.：2905-62-6
Empirical Formula: C7H3Cl3O
Molecular Weight: 209.46
MDL number: MFCD00009817
EINECS: 220-813-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-24 19:19:26

What is 3,5-Dichlorobenzoyl chloride?

Chemical properties

clear colorless to light yellow liquid or low

The Uses of 3,5-Dichlorobenzoyl chloride

3,5-Dichlorobenzoyl chloride is a useful intermediate for organic synthesis and other pharmaceutical processes.

The Uses of 3,5-Dichlorobenzoyl chloride

3,5-Dichlorobenzoyl chloride has been used in the preparation of:

N-(1,1-dimethylpropynyl)-3,5-dichlorobenzamide, herbicide
(3,5-dichlorophenyl)(2-(4-methoxyphenyl)-5-methylbenzofuran-3-yl)methanone

Flammability and Explosibility

Non flammable

Synthesis

3,5-Dichlorobenzoyl chloride is obtained by reacting by aryl carboxylic acid with DMF.Dissolve aryl carboxylic acid (10.0 mmol) in 50 mL DCM with drops of DMF to a 100 mL roundbottomed flask. Cool the mixture to 0°C. Add oxalyl chloride (20.0 mmol, 2.0 equivalents) dropwise to the reaction mixture. Allow the reaction mixture to react for another 4 hours. Concentrate the solvent in vacuo. Use the remaining residue directly.
Fig The synthetic method of 3,5-Dichlorobenzoyl chloride

Properties of 3,5-Dichlorobenzoyl chloride

Melting point:	28 °C (lit.)
Boiling point:	135-137 °C/25 mmHg (lit.)
Density	135
vapor pressure	0.1 mm Hg ( 32 °C)
refractive index	n20/D 1.582(lit.)
Flash point:	>230 °F
storage temp.	Refrigerator (+4°C)
solubility	soluble in Benzene,Toluene
form	powder to lump to clear liquid
color	White or Colorless to Almost white or Almost colorless
Sensitive	Moisture Sensitive
BRN	1940681
CAS DataBase Reference	2905-62-6(CAS DataBase Reference)
NIST Chemistry Reference	3,5-Dichlorobenzoyl chloride(2905-62-6)
EPA Substance Registry System	Benzoyl chloride, 3,5-dichloro- (2905-62-6)

Safety information for 3,5-Dichlorobenzoyl chloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.