2,6-Dichloro-5-fluoronicotinamide
- CAS NO.：113237-20-0
- Empirical Formula: C6H3Cl2FN2O
- Molecular Weight: 209.01
- MDL number: MFCD01571365
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 13:52:09
What is 2,6-Dichloro-5-fluoronicotinamide?
The Uses of 2,6-Dichloro-5-fluoronicotinamide
2,6-Dichloro-5-fluoronicotinamide is a fluorinated pharmaceutical intermediate compound used in the synthesis of Sotorasib and AMG 510. Sotorasib is a RAS GTPase family inhibitor used for the treatment of KRAS-mutated solid tumours including non-small cell lung cancer (NSCLC) and colorectal cancer.
Properties of 2,6-Dichloro-5-fluoronicotinamide
| Melting point: | 160-162 |
| Boiling point: | 259.0±40.0 °C(Predicted) |
| Density | 1.614±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 13.36±0.50(Predicted) |
| form | crystalline solid |
| color | White |
| InChI | InChI=1S/C6H3Cl2FN2O/c7-4-2(6(10)12)1-3(9)5(8)11-4/h1H,(H2,10,12) |
Safety information for 2,6-Dichloro-5-fluoronicotinamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 2,6-Dichloro-5-fluoronicotinamide
| InChIKey | ZVYNUGSPFZCYEV-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(Cl)=C(F)C=C1C(N)=O |
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![2,6-DICHLORO-5-FLUORO-N-[3-(TRIFLUOROMETHYL)PHENYL]NICOTINAMIDE](https://img.chemicalbook.in/StructureFile/ChemBookStructure4/GIF/CB9775976.gif)
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