2,5-Dimethyl pyrazine
- CAS NO.:123-32-0
- Empirical Formula: C6H8N2
- Molecular Weight: 108.14
- MDL number: MFCD00006147
- EINECS: 204-618-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 18:15:48
What is 2,5-Dimethyl pyrazine?
Chemical properties
clear colorless to pale yellow liquid
Chemical properties
2,5-Dimethylpyrazine has a characteristic odor of earthy, potato-like odor.
Occurrence
Reported to be present in bakery products, roasted barley, cocoa products, roasted coffee, dairy products, pork, peanuts, pecans, filberts, popcorn, potato products, rum and whiskey, soy products; a volatile component in roasted filberts and in potato chips; reportedly identified in the fat of cooked beef; also reported found in toasted off-flavors. Also reported in cheeses, butter, boiled eggs, grilled beef, tea, barley, oats, oatmeal, soybeans, heated beans, kohlrabi, shrimp and mushrooms. Also reported found in coffee, potato chips and shrimp
The Uses of 2,5-Dimethyl pyrazine
2,5-Dimethylpyrazine is used as a reagent in the synthesis of bone-targeted proteasome inhibitors for multiple myeloma (MM). 2,5-Dimethylpyrazine is also used in the preparation of 3-Methyl-2,5-bis-(2-hydroxyethyl)pyrazine (M295340); a degredation product of Clavulanic Acid (C563750) which is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
Preparation
By the interaction of acrolein and ammonia when heated in glycerol in the presence of ammonium salts; by self-condensation of aminoacetone, followed by oxidation with mercury chloride.
Definition
ChEBI: 2,5-Dimethylpyrazine is a member of pyrazines.
Aroma threshold values
Detection: 80 ppb to 1.8 ppm
Taste threshold values
Taste characteristics at 7.5 ppm: musty, potato, cocoa and nutty with a fatty and oily nuance
General Description
2,5-Dimethylpyrazine is a pyrazine compound that is mainly formed in food products such as cooked rice or roasted peanuts due to the Maillard reaction between sugars and proteins during cooking or roasting process.
Safety Profile
Moderately toxic by ingestion and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx
Purification Methods
Purify it via its picrate (m 150o) which is decomposed with a base (e,g, KOH) and distilled. [Wiggins and Wise J Chem Soc 4780 1956]. [Beilstein 23/5 V 403.]
Properties of 2,5-Dimethyl pyrazine
Melting point: | 15°C |
Boiling point: | 155 °C (lit.) |
Density | 0.99 g/mL at 25 °C (lit.) |
refractive index | n |
FEMA | 3272 | 2,5-DIMETHYLPYRAZINE |
Flash point: | 147 °F |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
form | Liquid |
pka | 2.21±0.10(Predicted) |
Specific Gravity | 0.990 |
color | Clear colorless to pale yellow |
PH | 7 (H2O) |
Odor | at 0.10 % in dipropylene glycol. nutty roasted baked potato |
Sensitive | Hygroscopic |
JECFA Number | 766 |
BRN | 107052 |
Dielectric constant | 2.4399999999999999 |
CAS DataBase Reference | 123-32-0(CAS DataBase Reference) |
NIST Chemistry Reference | Pyrazine, 2,5-dimethyl-(123-32-0) |
EPA Substance Registry System | Pyrazine, 2,5-dimethyl- (123-32-0) |
Safety information for 2,5-Dimethyl pyrazine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for 2,5-Dimethyl pyrazine
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