2,5-Dimethoxycinnamic acid

CAS NO.：10538-51-9
Empirical Formula: C11H12O4
Molecular Weight: 208.21
MDL number: MFCD00004378
EINECS: 234-114-9
SAFETY DATA SHEET (SDS)
Update Date: 2023-09-05 17:53:06

What is 2,5-Dimethoxycinnamic acid?

Chemical properties

yellow powder

The Uses of 2,5-Dimethoxycinnamic acid

2,5-Dimethoxycinnamic acid can be used as a pharmaceutical intermediate, and can be used in the synthesis of vasodilators such as cinnepazide.

Preparation

Synthesis of 2,5-dimethoxycinnamic acid: 2,5-dimethoxybenzaldehyde, malonic acid and pyridine were added to 100ml three necks, piperidine was added at 90°C, refluxed for 2h, cooled to room temperature, and added 3mol/L hydrochloric acid, resulting in a large amount of white precipitate, suction filtration, the filter cake is washed with water, reconstituted with ethanol, after drying, 2,5-dimethoxycinnamic acid was obtained as pale yellow needle crystals.

Definition

ChEBI: 2,5-Dimethoxycinnamic acid is a hydroxycinnamic acid.

General Description

2,5-Dimethoxycinnamic acid forms 1:1 molecular complex with 3,5-dinitrocinnamic acid.

Properties of 2,5-Dimethoxycinnamic acid

Melting point:	147-150°C
Boiling point:	267.4°C (rough estimate)
Density	1.0627 (rough estimate)
refractive index	1.4389 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	4.40±0.10(Predicted)
form	powder to crystal
color	Light orange to Yellow to Green
CAS DataBase Reference	10538-51-9(CAS DataBase Reference)

Safety information for 2,5-Dimethoxycinnamic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.