2-(Hydroxymethyl)pyridine
Synonym(s):ω-Hydroxy-2-picoline;2-(Hydroxymethyl)pyridine;2-Pyridyl carbinol
- CAS NO.:586-98-1
- Empirical Formula: C6H7NO
- Molecular Weight: 109.13
- MDL number: MFCD00006348
- EINECS: 209-592-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 2-(Hydroxymethyl)pyridine?
Chemical properties
CLEAR COLORLESS TO YELLOW OR BROWN LIQUID
The Uses of 2-(Hydroxymethyl)pyridine
decongestant
The Uses of 2-(Hydroxymethyl)pyridine
A pyridylalcohol with hypoglycemic activity and potential apoptotic effect in human leukemia cells.
The Uses of 2-(Hydroxymethyl)pyridine
2-Pyridinemethanol is used as a pyridylalcohol with hypoglycemic activity.
Preparation
The preparation of 2-(Hydroxymethyl)pyridine is as follows:NaOH (0.5 g, 12.5 mmol), Al2O3 (2.0 g, 19.6 mmol), aldehyde 1f-g (2 mmol) and H2O (400 μL) were grinded in a mortar. Next, the paste were placed in a glass 10 mL pressure vials and reaction was carried out in microwave reactor: standard mode (200 W), 100 °C, 2 min. After that, reaction mixture was extracted with DCM (2 × 20 mL). Organic layer was evaporated under reduce pressure yielding 2f-g. Solid residue was washed by water (2 × 15 mL). Aqueous phase was acidify with 1N HCl to pH 5.5 and centrifuged. After that aqueous layer was pour down and precipitate was lyophilisated. Products 3f-g were obtained as white solids.
Definition
ChEBI: 2-Pyridinylmethanol is a member of pyridines.
Properties of 2-(Hydroxymethyl)pyridine
Melting point: | 5 °C |
Boiling point: | 112-113 °C/16 mmHg (lit.) |
Density | 1.131 g/mL at 25 °C (lit.) |
vapor pressure | 3.47Pa at 25℃ |
refractive index | n |
Flash point: | >230 °F |
storage temp. | 2-8°C |
solubility | miscible |
form | Liquid |
pka | 13.48±0.10(Predicted) |
Specific Gravity | 1.131 |
color | Clear colorless to yellow or brown |
PH | 6-8 (100g/l, H2O, 20℃) |
Odor | pyridine odor |
Water Solubility | miscible |
Sensitive | Hygroscopic |
BRN | 107849 |
CAS DataBase Reference | 586-98-1(CAS DataBase Reference) |
NIST Chemistry Reference | Piconol(586-98-1) |
Safety information for 2-(Hydroxymethyl)pyridine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-(Hydroxymethyl)pyridine
InChIKey | SHNUBALDGXWUJI-UHFFFAOYSA-N |
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