2,4-Thiazolidinedione

CAS NO.：2295-31-0
Empirical Formula: C3H3NO2S
Molecular Weight: 117.13
MDL number: MFCD00005478
EINECS: 218-941-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-25 16:21:11

What is 2,4-Thiazolidinedione?

Chemical properties

White to Off-White Powder

The Uses of 2,4-Thiazolidinedione

2,4-Thiazolidinedione may be used in the synthesis of sixteen 5-arylidene-2,4-thiazolidinediones, via ultrasound-promoted aldol condensation reaction. It may be used as starting material for the synthesis of drugs with antihyperglycemic activity.

The Uses of 2,4-Thiazolidinedione

Inhibitor of enzyme

Definition

ChEBI: A thiazolidenedione carrying oxo substituents at positions 2 and 4.

General Description

2,4-Thiazolidinedione is a well-known peroxisome proliferator-activated receptors (PPAR) activator. Its effect on aging process using kidneys from Fischer 344 rats has been reported. A library of conjugates of 2,4-thiazolidinedione has been synthesized by Knoevenagel condensation followed by reduction using hydrogen gas and Pd/C catalyst. Knoevenagel condensation of various aromatic aldehydes with 2,4-thiazolidinedione in polyethylene glycol-300 has been reported.

Flammability and Explosibility

Not classified

Solubility

Soluble in water (30 mg/ml at 3°C), methanol, DMSO, ethanol, and ethyl ether.

Properties of 2,4-Thiazolidinedione

Melting point:	125-127 °C (lit.)
Boiling point:	178-179 °C (19 mmHg)
Density	1.408 (estimate)
vapor pressure	0Pa at 25℃
refractive index	1.5130 (estimate)
Flash point:	178-179°C/19mm
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	6.50±0.10(Predicted)
form	Crystalline Powder
color	Slightly yellow
Water Solubility	Soluble in water (30 mg/ml at 3°C), methanol, DMSO, ethanol, and ethyl ether.
BRN	110700
CAS DataBase Reference	2295-31-0(CAS DataBase Reference)
NIST Chemistry Reference	2,4-Thiazolidinedione(2295-31-0)
EPA Substance Registry System	2,4-Thiazolidinedione (2295-31-0)

Safety information for 2,4-Thiazolidinedione

Signal word	Warning
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P321:Specific treatment (see … on this label). P405:Store locked up.