2,4-Thiazolidinedione
- CAS NO.：2295-31-0
- Empirical Formula: C3H3NO2S
- Molecular Weight: 117.13
- MDL number: MFCD00005478
- EINECS: 218-941-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:15:30
What is 2,4-Thiazolidinedione?
Chemical properties
White to Off-White Powder
The Uses of 2,4-Thiazolidinedione
Inhibitor of enzyme
The Uses of 2,4-Thiazolidinedione
2,4-Thiazolidinedione may be used in the synthesis of sixteen 5-arylidene-2,4-thiazolidinediones, via ultrasound-promoted aldol condensation reaction. It may be used as starting material for the synthesis of drugs with antihyperglycemic activity.
Definition
ChEBI: A thiazolidenedione carrying oxo substituents at positions 2 and 4.
General Description
2,4-Thiazolidinedione is a well-known peroxisome proliferator-activated receptors (PPAR) activator. Its effect on aging process using kidneys from Fischer 344 rats has been reported. A library of conjugates of 2,4-thiazolidinedione has been synthesized by Knoevenagel condensation followed by reduction using hydrogen gas and Pd/C catalyst. Knoevenagel condensation of various aromatic aldehydes with 2,4-thiazolidinedione in polyethylene glycol-300 has been reported.
Flammability and Explosibility
Not classified
Solubility
Soluble in water (30 mg/ml at 3°C), methanol, DMSO, ethanol, and ethyl ether.
Properties of 2,4-Thiazolidinedione
| Melting point: | 125-127 °C (lit.) |
| Boiling point: | 178-179 °C (19 mmHg) |
| Density | 1.408 (estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.5130 (estimate) |
| Flash point: | 178-179°C/19mm |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 6.50±0.10(Predicted) |
| form | Crystalline Powder |
| color | Slightly yellow |
| Water Solubility | Soluble in water (30 mg/ml at 3°C), methanol, DMSO, ethanol, and ethyl ether. |
| BRN | 110700 |
| CAS DataBase Reference | 2295-31-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 2,4-Thiazolidinedione(2295-31-0) |
| EPA Substance Registry System | 2,4-Thiazolidinedione (2295-31-0) |
Safety information for 2,4-Thiazolidinedione
| Signal word | Warning |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P321:Specific treatment (see … on this label). P405:Store locked up. |
Computed Descriptors for 2,4-Thiazolidinedione
| InChIKey | ZOBPZXTWZATXDG-UHFFFAOYSA-N |
2,4-Thiazolidinedione manufacturer
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