2,4-Dichloropyridine-3-carboxaldehyde

Synonym(s):2,4-Dichloronicotinaldehyde

CAS NO.：134031-24-6
Empirical Formula: C6H3Cl2NO
Molecular Weight: 176
MDL number: MFCD07437909
SAFETY DATA SHEET (SDS)
Update Date: 2023-10-20 10:10:04

2,4-Dichloropyridine-3-carboxaldehyde Structural

What is 2,4-Dichloropyridine-3-carboxaldehyde?

Chemical properties

Yellow solid

Synthesis

To a solution of 2,4-dichloropyridine (2 g, 13.51 mmol) in tetrahydrofuran (20 mL) at -78° C added LDA in THF/heptane/ethylbenzene (2M, 8.11 mL, 16.22 mmol) and the solution was stirred for 30 min. DMF (10.46 mL, 135 mmol) was added and the solution was stirred for 1 h and then warmed RT. The reaction mixture was quenched with saturated NH4Cl solution and diluted with ethyl acetate (50 mL). The organic layer was washed with saturated NaHCO3 (2*10 mL), water (20 mL), dried over Na2SO4, and concentrated under reduced pressure to afford 2,4-dichloronicotinaldehyde (2 g, 11.36 mmol, 84% yield). 2,4-Dichloropyridine-3-carboxaldehyde

Properties of 2,4-Dichloropyridine-3-carboxaldehyde

Melting point:	72-75℃
Boiling point:	261.8±35.0 °C(Predicted)
Density	1.488±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	powder to crystal
pka	-1.17±0.10(Predicted)
color	White to Orange to Green
Sensitive	Air Sensitive

Safety information for 2,4-Dichloropyridine-3-carboxaldehyde

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.