2,4-Dichloro-5-fluoropyrimidine

Chemical properties

2,4-Dichloro-5-fluoropyrimidine is Yellow to Orange Crystalline Solid

The Uses of 2,4-Dichloro-5-fluoropyrimidine

2,4-Dichloro-5-fluoropyrimidine is used in the synthesis of two glucuronic derivatives of 5-fluorouracil as neoplasm inhibitors. It is used in the synthesis of two glucuronic derivatives of 5-fluorouracil as neoplasm inhibitors.

The Uses of 2,4-Dichloro-5-fluoropyrimidine

2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize:

• 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors.
• A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors.
• 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors.
• 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA.
• 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst.
• 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.

Flammability and Explosibility

Not classified