Acute toxicity - Category 3, Oral
Skin irritation, Category 2
Serious eye damage, Category 1
Specific target organ toxicity – single exposure, Category 3
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 4
H301 Toxic if swallowed
H315 Causes skin irritation
H318 Causes serious eye damage
H335 May cause respiratory irritation
H413 May cause long lasting harmful effects to aquatic life
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P317 Get medical help.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
no data available
Fresh air, rest. Refer for medical attention.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .
SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes, mucous membranes and upper respiratory tract. Depending on the intensity and duration of exposure, effects may vary from mild irritation to severe destruction of tissue. Prolonged contact can cause eye damage. It can also cause irritation of the nose and throat. Exposure to this type of compound may cause profuse sweating, intense thirst, abdominal pain, nausea, vomiting, diarrhea, cyanosis from methemoglobinemia, hyperactivity, stupor, blood pressure fall, hyperpnea, hemolysis, convulsions, collapse, coma and pulmonary edema followed by pneumonia. If death from respiratory failure is not immediate, jaundice and oliguria or anuria may occur. Other symptoms of exposure to this type of compound may include headache, dizziness, rapid and difficult breathing, weakness, severe burns and internal damage. Chronic exposure may result in digestive disturbances, nervous disorders, skin eruptions and liver and kidney damage. Skin contact with this type of compound may result in softening and whitening of the skin, followed by the development of painful burns. Prolonged contact may lead to dermatitis. Local contact may also result in painless blanching or erythema and corrosion of the skin. Skin sensitivity reactions occur occasionally. ACUTE/CHRONIC HAZARDS: This compound is highly toxic by inhalation, ingestion and skin absorption. It is an irritant of the skin, eyes, mucous membranes and upper respiratory tract; and prolonged contact may result in severe irritation or destruction of tissue. It is also an irritant of the nose and throat. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and hydrogen chloride gas. (NTP, 1992)
The compounds are readily absorbed from the gastroenteric tract and from parenteral sites of injection. Chlorophenols
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)
In case of fire in the surroundings, use appropriate extinguishing media.
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs.
no data available
no data available
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Wear safety goggles or eye protection in combination with breathing protection if powder.
Protective gloves. Protective clothing.
Use local exhaust or breathing protection.
no data available
PHYSICAL DESCRIPTION: Leaflets (from ligroin) or light beige powder. (NTP, 1992)
Leaf, from ligroin
no data available
114-116°C
261°C at 760mmHg
Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.
no data available
111.7°C
no data available
288°C
no data available
no data available
less than 1 mg/mL at 68° F (NTP, 1992)
log Kow = 3.88
Pa at 100°C: 130
1.709g/cm3
(air = 1): 8.0
no data available
Decomposes on heating and on contact with strong oxidants. This produces toxic and corrosive fumes of hydrogen chloride. The substance is a weak acid.
no data available
2,3,5,6-TETRACHLOROPHENOL is incompatible with acid chlorides, acid anhydrides and oxidizing agents. (NTP, 1992).
no data available
no data available
When heated to decomposition it emits toxic fumes of hydrogen chloride
no data available
no data available
no data available
no data available
no data available
no data available
The substance is irritating to the eyes, skin and respiratory tract. See Notes.
Repeated or prolonged contact with skin may cause dermatitis.
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.
An inoculum, acclimated to pentachlorophenol for 10 days, was able to biodegrade 2,3,5,6-tetrachlorophenol, initially at 3.80 uM, by 62.1% in 1.5 days under methanogenic conditions(1). A lag period of 26 days was required before degradation of 2,3,5,6-tetrachlorophenol proceeded in an aerobic sediment:water system(2). Groundwater obtained from a contaminated aquifer(due to a coal tar distillation and wood treatment facility) containing 2,3,5,6-tetrachlorophenol, at 0.13 mg/l, was used in two anaerobic digestor experiments(3). No loss was seen in one digestor run in semicontinuous mode over 84 hours; in the second digestor, which had run continuously, only 0.05 mg/l 2,3,5,6-tetrachlorophenol was found after 8 weeks (61.5% biodegradation)(3).
A BCF value of 142 was measured in whole fish samples (lipid-based BCF=1451) of juvenile American flagfish during a 28 day flow-through exposure experiment; 2,3,5,6-tetrachlorophenol was present at 4.1 ug/l(1). A depuration half-life of 0.40 days was measured for this compound in the same experiment(1). According to a classification scheme(2), this BCF value indicates that the potential for bioconcentration in aquatic organisms is high but as elimination is rapid only short-term bioaccumulation is expected(SRC).
The Koc of 2,3,5,6-tetrachlorophenol is estimated as approximately 3100(SRC), using a log Kow value of 3.88(1) and a regression-derived equation(2,SRC). According to a classification scheme(3), this estimated Koc value suggests that 2,3,5,6-tetrachlorophenol is expected to have slight mobility in soil(SRC). In an aqueous adsorption study, 1546 pg/g 2,3,5,6-/2,3,4,6-tetrachlorophenol was found in the sediment, 260 pg/g in suspended matter, and 41 pg/g in the water; the sediment to water ratio is 38 and suspended matter to water ratio is 6.3(4).
no data available
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
ADR/RID: UN2020 (For reference only, please check.)
IMDG: UN2020 (For reference only, please check.)
IATA: UN2020 (For reference only, please check.)
ADR/RID: CHLOROPHENOLS, SOLID (For reference only, please check.)
IMDG: CHLOROPHENOLS, SOLID (For reference only, please check.)
IATA: CHLOROPHENOLS, SOLID (For reference only, please check.)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
ADR/RID: No
IMDG: No
IATA: No
no data available
no data available
No data are available on this isomer but a mixture of tetrachlorophenols may cause irritation of the skin, eyes and respiratory tract.These substances may cause acute metabolic effects resulting in damage in several organs notably CNS.Some technical products may contain highly toxic impurities including polychlorinated dibenzo-p-dioxins and furans.Depending on the degree of exposure, periodic medical examination is indicated.