2,2,2-Trichloroethyl chloroformate

Synonym(s):2,2,2-Trichloroethoxycarbonyl chloride

CAS NO.：17341-93-4
Empirical Formula: C3H2Cl4O2
Molecular Weight: 211.86
MDL number: MFCD00000810
EINECS: 241-363-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-04-23 14:28:52

2,2,2-Trichloroethyl chloroformate Structural

What is 2,2,2-Trichloroethyl chloroformate?

Chemical properties

Clear light yellow liquid

The Uses of 2,2,2-Trichloroethyl chloroformate

2,2,2-Trichloroethyl chloroformate is used as a protecting reagent for aliphatic and aromatic hydroxyl and amino groups. It is used as derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples, during N-demethylation of dextromethorphan. It was used as starting reagent during the synthesis of 6-Nor-9,10-dihydrolysergic acid methyl ester.

The Uses of 2,2,2-Trichloroethyl chloroformate

2,2,2-Trichloroethyl chloroformate was used as:

derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples
starting reagent during the synthesis of 6-nor-9,10-dihydrolysergic acid methyl ester (IV)
reagent during N-demethylation of dextromethorphan
protecting group reagent for amines and alcohols

What are the applications of Application

2,2,2-Trichloroethyl chloroformate is a protecting reagent for aliphatic and aromatic hydroxyl and amino groups

Properties of 2,2,2-Trichloroethyl chloroformate

Melting point:	1°C
Boiling point:	171-172 °C (lit.)
Density	1.539 g/mL at 25 °C (lit.)
vapor pressure	0.06 psi ( 20 °C)
refractive index	n20/D 1.471(lit.)
Flash point:	>100°C
storage temp.	2-8°C
solubility	soluble in Chloroform, Ethyl Acetate
form	Liquid
color	Clear light yellow
Water Solubility	Soluble in Ether, Benzene, Chloroform, Ethanol. Insoluble in water.
Sensitive	Moisture Sensitive
BRN	970619
CAS DataBase Reference	17341-93-4(CAS DataBase Reference)
NIST Chemistry Reference	Carbonochloridic acid, 2,2,2-trichloroethyl ester(17341-93-4)
EPA Substance Registry System	Carbonochloridic acid, 2,2,2-trichloroethyl ester (17341-93-4)

Safety information for 2,2,2-Trichloroethyl chloroformate

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H314:Skin corrosion/irritation H331:Acute toxicity,inhalation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.