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HomeProduct name list2,2'-Furoin

2,2'-Furoin

  • CAS NO.:552-86-3
  • Empirical Formula: C10H8O4
  • Molecular Weight: 192.17
  • MDL number: MFCD00003246
  • EINECS: 209-024-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-05-20 14:01:34
2,2'-Furoin Structural

What is 2,2'-Furoin?

Chemical properties

LIGHT YELLOW TO LIGHT BROWN AMORPHOUS POWDER

The Uses of 2,2'-Furoin

Furoin was used as fluorogenic reagent for the selective and sensitive liquid chromatographic determination of various guanidines.

Preparation

2,2'-Furoin is prepared by the condensation of furfural with benzoin under the catalysis of potassium cyanide. 8L of water, 3L of ethanol, and 4kg of furfural were heated to 60-70°C on a water bath, and a solution of 200g potassium cyanide dissolved in 600Chemicalbookml of water was slowly added under stirring. The reaction exotherm automatically heated up to 80-90 ° C, and crystals were precipitated later. After standing, filter, wash the crystals with water and methanol until the washing is colorless, and recrystallize with ethanol, which is the finished product of bran coupler.

Purification Methods

It crystallises from MeOH (charcoal) and distils in a vacuum. [Hartman & Dickey J Am Chem Soc 55 1228 1933.] The (-)-enantiomer crystallises from toluene or EtOH with m 131-131o, and [] 20 -4.9o (dioxane) [Neuberg et al. Arch Biochem 1 393 1943, Beilstein 19 H 204, 19 I 710, 19 II 224, 19 III/IV 2543.]

Properties of 2,2'-Furoin

Melting point: 134-137 °C(lit.)
Boiling point: 248.14°C (rough estimate)
Density  1.0825 (rough estimate)
refractive index  1.4440 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  acetone: soluble0.25g/10 mL, clear, colorless to deep brown-yellow
pka 11.62±0.20(Predicted)
form  powder to crystal
color  White to Light yellow to Light orange
BRN  383995
CAS DataBase Reference 552-86-3(CAS DataBase Reference)
NIST Chemistry Reference Ethanone, 1,2-di-2-furanyl-2-hydroxy-(552-86-3)
EPA Substance Registry System Ethanone, 1,2-di-2-furanyl-2-hydroxy- (552-86-3)

Safety information for 2,2'-Furoin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2,2'-Furoin

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