2,2'-Furoin
- CAS NO.:552-86-3
- Empirical Formula: C10H8O4
- Molecular Weight: 192.17
- MDL number: MFCD00003246
- EINECS: 209-024-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 13:37:16
What is 2,2'-Furoin?
Chemical properties
LIGHT YELLOW TO LIGHT BROWN AMORPHOUS POWDER
The Uses of 2,2'-Furoin
Furoin was used as fluorogenic reagent for the selective and sensitive liquid chromatographic determination of various guanidines.
Preparation
2,2'-Furoin is prepared by the condensation of furfural with benzoin under the catalysis of potassium cyanide. 8L of water, 3L of ethanol, and 4kg of furfural were heated to 60-70°C on a water bath, and a solution of 200g potassium cyanide dissolved in 600Chemicalbookml of water was slowly added under stirring. The reaction exotherm automatically heated up to 80-90 ° C, and crystals were precipitated later. After standing, filter, wash the crystals with water and methanol until the washing is colorless, and recrystallize with ethanol, which is the finished product of bran coupler.
Purification Methods
It crystallises from MeOH (charcoal) and distils in a vacuum. [Hartman & Dickey J Am Chem Soc 55 1228 1933.] The (-)-enantiomer crystallises from toluene or EtOH with m 131-131o, and [] 20 -4.9o (dioxane) [Neuberg et al. Arch Biochem 1 393 1943, Beilstein 19 H 204, 19 I 710, 19 II 224, 19 III/IV 2543.]
Properties of 2,2'-Furoin
Melting point: | 134-137 °C(lit.) |
Boiling point: | 248.14°C (rough estimate) |
Density | 1.0825 (rough estimate) |
refractive index | 1.4440 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | acetone: soluble0.25g/10 mL, clear, colorless to deep brown-yellow |
pka | 11.62±0.20(Predicted) |
form | powder to crystal |
color | White to Light yellow to Light orange |
BRN | 383995 |
CAS DataBase Reference | 552-86-3(CAS DataBase Reference) |
NIST Chemistry Reference | Ethanone, 1,2-di-2-furanyl-2-hydroxy-(552-86-3) |
EPA Substance Registry System | Ethanone, 1,2-di-2-furanyl-2-hydroxy- (552-86-3) |
Safety information for 2,2'-Furoin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,2'-Furoin
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
You may like
-
552-86-3 FUROIN (1,2-di(2-furyl)-2-hydroxyethan-1-one) 98%View Details
552-86-3 -
Furoin 95% CAS 552-86-3View Details
552-86-3 -
Furoin CAS 552-86-3View Details
552-86-3 -
1975-50-4 98%View Details
1975-50-4 -
2-HYDROXY BENZYL ALCOHOL 98%View Details
90-01-7 -
2-Chloro-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 221615-75-4 98%View Details
221615-75-4 -
14714-50-2 (2-Hydroxyphenyl)acetonitrile 98+View Details
14714-50-2 -
118753-70-1 98+View Details
118753-70-1