2,2-Dimethoxypropane

Synonym(s):2,2-Dimethoxypropane;Acetone dimethyl acetal

CAS NO.：77-76-9
Empirical Formula: C5H12O2
Molecular Weight: 104.15
MDL number: MFCD00008479
EINECS: 201-056-0
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is 2,2-Dimethoxypropane?

Chemical properties

colourless liquid; B.P. 83℃. Ethereal odor. Soluble in alcohol, miscible with ess, oils and perfume chemicals. Stable when pure and at room temp. Decomposes into Acetone and Methanol during heating in presence of moisture or traces of mineral acid. Presumably not used in flavors. Rarely used in perfumes - for ethereal top-notes and "alcohol-like" effects. Produced synthetically via orthoformic ester or vinyl ether. Also from formiminomethyl-ether hydrochloride.

The Uses of 2,2-Dimethoxypropane

2,2-Dimethoxypropane(DMP) is used in histology and considered to be more efficient than ethanol for the dehydration of animal tissue.

The Uses of 2,2-Dimethoxypropane

2,2-Dimethoxypropane acts as a dehydrating agent. It also serves as an intermediate in the synthesis of vitamin E, vitamin A and various carotenoids such as astaxanthin. It is used as a reagent for the preparation of 1,2-diols, acetonides, isopropylidene derivatives of sugars, nucleosides, methyl esters of amino acids and enol ethers.

What are the applications of Application

2,2-Dimethoxypropane is a starting material and efficient tissue dehydration agent

General Description

2,2-Dimethoxypropane is an organic compound, which may be used as a protecting agent in the process of the synthesis of structurally related alkaloids like narciclasine and lycoricidine using phenylbromide as the starting material.

Properties of 2,2-Dimethoxypropane

Melting point:	-47 °C
Boiling point:	83 °C (lit.)
Density	0.847 g/mL at 25 °C (lit.)
vapor density	3.59 (vs air)
vapor pressure	60 mm Hg ( 15.8 °C)
refractive index	n20/D 1.378(lit.)
Flash point:	12 °F
storage temp.	Store below +30°C.
solubility	180g/l
form	Liquid
color	Clear colorless
Specific Gravity	0.852 (20/4℃)
explosive limit	31%, 58°F
Water Solubility	18 g/100 mL (25 ºC)
BRN	635678
Stability:	Stable. Highly flammable - note low flash point. Vapour may form an explosive mixture with air. May form explosive peroxides when exposed to air. Incompatible with strong oxidizing agents.
CAS DataBase Reference	77-76-9(CAS DataBase Reference)
NIST Chemistry Reference	2,2-Dimethoxypropane(77-76-9)
EPA Substance Registry System	Propane, 2,2-dimethoxy- (77-76-9)

Safety information for 2,2-Dimethoxypropane

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.