Senicapoc
- CAS NO.：289656-45-7
- Empirical Formula: C20H15F2NO
- Molecular Weight: 323.34
- MDL number: MFCD09027349
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-14 20:10:21
What is Senicapoc?
Description
Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (; IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per day) reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease. It inhibits IL-2, IFN-γ, IL-12, and IL-17A production in CD3+ T cells stimulated with phorbol 12-myristate 13-acetate (PMA; ) and ionomycin (Item Nos. 10004974 | 11932) when used at a concentration of 1 μM. Senicapoc (100 mg/kg) increases the paw withdrawal threshold in a rat model of chronic constriction injury (CCI) of the sciatic nerve.
The Uses of Senicapoc
Treatment of disorders mediated by a calcium activated intermediate conductance potassium ion channel antagonist.
Properties of Senicapoc
| Melting point: | 180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2)) |
| Boiling point: | 460.7±45.0 °C(Predicted) |
| Density | 1.250±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO : 50 mg/mL (154.64 mM; Need ultrasonic) |
| form | Powder |
| pka | 15.41±0.50(Predicted) |
| color | White to yellow |
Safety information for Senicapoc
Computed Descriptors for Senicapoc
New Products
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