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HomeProduct name list2,6-Difluorobenzamide

2,6-Difluorobenzamide

  • CAS NO.:18063-03-1
  • Empirical Formula: C7H5F2NO
  • Molecular Weight: 157.12
  • MDL number: MFCD00007972
  • EINECS: 241-972-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-30 18:52:02
2,6-Difluorobenzamide Structural

What is 2,6-Difluorobenzamide?

Description

2,6-Difluorobenzamide is a major metabolite of pesticide diflubenzuron and has been quantitated by HPLC/diode-array method.

Description

2,6-Difluorobenzamide is a white powdery crystal, insoluble in water. It can be obtained by hydrolysis of 2,6-difluorobenzonitrile. 2,6-Difluorobenzamide is an important intermediate in the synthesis process of benzoylurea insecticides, which is used to synthesize the next intermediate 2,6-difluorobenzoyl isocyanate, and finally obtain flubolurea, pyruron, fluridin, lice mite urea and other pesticide varieties. It can also be directly used to synthesize pyruron and flubolea. 2,6-Difluorobenzamide can inhibit the bacterial cell division protein FtsZ[1].

Chemical properties

white to yellowish powder

The Uses of 2,6-Difluorobenzamide

2,6-Difluorobenzamide (CAS# 18063-03-1) is a useful building block used in the synthesis of (E)-3-methyleneisoindolin-1-ones via oxidative annulation acrylates.

What are the applications of Application

2,6-Difluorobenzamide is a major metabolite of diflubenzuron

Preparation

2,6-Difluorobenzamide is obtained by hydrolysis of 2,6-difluorobenzonitrile.

References

[1] Straniero V, et al. 2,6-Difluorobenzamide inhibitors of the bacterial cell division protein FtsZ: design, synthesis and Structure Activity Relationship study. ChemMedChem, 2017; 12: 1303-1318.

Properties of 2,6-Difluorobenzamide

Melting point: 145-148 °C (lit.)
Boiling point: 51-52C/15Tor
Density  1,199g/cm
refractive index  1,508
storage temp.  Sealed in dry,Room Temperature
solubility  ethanol: soluble5%, clear to turbid, colorless to light yellow
form  Solid
pka 14.54±0.50(Predicted)
color  Off-White
BRN  2047480
CAS DataBase Reference 18063-03-1(CAS DataBase Reference)
NIST Chemistry Reference Benzamide, 2,6-difluoro-(18063-03-1)
EPA Substance Registry System Benzamide, 2,6-difluoro- (18063-03-1)

Safety information for 2,6-Difluorobenzamide

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

Computed Descriptors for 2,6-Difluorobenzamide

InChIKey AVRQBXVUUXHRMY-UHFFFAOYSA-N

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