2,6-Difluorobenzamide
- CAS NO.:18063-03-1
- Empirical Formula: C7H5F2NO
- Molecular Weight: 157.12
- MDL number: MFCD00007972
- EINECS: 241-972-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-30 18:52:02
What is 2,6-Difluorobenzamide?
Description
2,6-Difluorobenzamide is a major metabolite of pesticide diflubenzuron and has been quantitated by HPLC/diode-array method.
Description
2,6-Difluorobenzamide is a white powdery crystal, insoluble in water. It can be obtained by hydrolysis of 2,6-difluorobenzonitrile. 2,6-Difluorobenzamide is an important intermediate in the synthesis process of benzoylurea insecticides, which is used to synthesize the next intermediate 2,6-difluorobenzoyl isocyanate, and finally obtain flubolurea, pyruron, fluridin, lice mite urea and other pesticide varieties. It can also be directly used to synthesize pyruron and flubolea. 2,6-Difluorobenzamide can inhibit the bacterial cell division protein FtsZ[1].
Chemical properties
white to yellowish powder
The Uses of 2,6-Difluorobenzamide
2,6-Difluorobenzamide (CAS# 18063-03-1) is a useful building block used in the synthesis of (E)-3-methyleneisoindolin-1-ones via oxidative annulation acrylates.
What are the applications of Application
2,6-Difluorobenzamide is a major metabolite of diflubenzuron
Preparation
2,6-Difluorobenzamide is obtained by hydrolysis of 2,6-difluorobenzonitrile.
References
[1] Straniero V, et al. 2,6-Difluorobenzamide inhibitors of the bacterial cell division protein FtsZ: design, synthesis and Structure Activity Relationship study. ChemMedChem, 2017; 12: 1303-1318.
Properties of 2,6-Difluorobenzamide
Melting point: | 145-148 °C (lit.) |
Boiling point: | 51-52C/15Tor |
Density | 1,199g/cm |
refractive index | 1,508 |
storage temp. | Sealed in dry,Room Temperature |
solubility | ethanol: soluble5%, clear to turbid, colorless to light yellow |
form | Solid |
pka | 14.54±0.50(Predicted) |
color | Off-White |
BRN | 2047480 |
CAS DataBase Reference | 18063-03-1(CAS DataBase Reference) |
NIST Chemistry Reference | Benzamide, 2,6-difluoro-(18063-03-1) |
EPA Substance Registry System | Benzamide, 2,6-difluoro- (18063-03-1) |
Safety information for 2,6-Difluorobenzamide
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for 2,6-Difluorobenzamide
InChIKey | AVRQBXVUUXHRMY-UHFFFAOYSA-N |
Abamectin manufacturer
Aarti Industries Limited (AIL)
AVIGYABIOSCIENCES PRIVATE LIMITED
Dr R R Organics
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