2-Phenylethylamine hydrochloride
Synonym(s):β-Phenylethylamine hydrochloride;Phenethylamine hydrochloride
- CAS NO.:156-28-5
- Empirical Formula: C8H12ClN
- Molecular Weight: 157.64
- MDL number: MFCD00012893
- EINECS: 205-849-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:15:30
What is 2-Phenylethylamine hydrochloride?
Description
2-
Chemical properties
White to Light yellow powder to crystal. soluble in water, alcohol, ether.
The Uses of 2-Phenylethylamine hydrochloride
2-Phenylethylamine hydrochloride is the hydrochloride salt form of 2-Phenylethylamine, which is an biogenic aromatic amine acting as a monoaminergic neuromodulator or a neurotransmitter in the human central nervous system. It is used to CNS stimulant.
Preparation
In a nitrogen environment, add the aliphatic nitro derivatives (0.6 mmol), pinacol borane (3.6 mmol, 6.0 equiv), tetrahydrofuran (2 mL), triethylboron (5 mol%), and potassium tert-butoxide (5 mol %) into a 10 mL sealed tube and then place it in a 100 oil bath with heating and stirring for 24 hours. At the end of the reaction, add 2mL of 1M hydrochloric acid aqueous solution to the reaction solution and stir at room temperature for 6 h. Finally, 2-Phenylethylamine hydrochloride is obtained by filtration.
Safety Profile
Poison by skin contact, subcutaneous, and intravenous routes. A human eye irritant. A skin irritant and possible sensitizer. Human systemic effects by ingestion: blood pressure lowering, anorexia. When heated to decomposition it emits very toxic fumes of
Properties of 2-Phenylethylamine hydrochloride
Melting point: | 220-222 °C(lit.) |
Boiling point: | 217 °C |
Flash point: | 81 °C |
storage temp. | Store at -20°C |
solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): 10 mg/ml |
form | Powder or Crystalline Powder |
color | White to off-white |
Merck | 14,6026 |
BRN | 3624163 |
InChI | InChI=1S/C8H11N.ClH/c9-7-6-8-4-2-1-3-5-8;/h1-5H,6-7,9H2;1H |
CAS DataBase Reference | 156-28-5(CAS DataBase Reference) |
NIST Chemistry Reference | 2-Phenylethylammonium chloride(156-28-5) |
EPA Substance Registry System | Benzeneethanamine, hydrochloride (156-28-5) |
Safety information for 2-Phenylethylamine hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Phenylethylamine hydrochloride
InChIKey | SKHIBNDAFWIOPB-UHFFFAOYSA-N |
SMILES | C1(CCN)=CC=CC=C1.Cl |
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