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HomeProduct name list2-Nitrophenylacetonitrile

2-Nitrophenylacetonitrile

  • CAS NO.:610-66-2
  • Empirical Formula: C8H6N2O2
  • Molecular Weight: 162.15
  • MDL number: MFCD00007183
  • EINECS: 210-231-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-12-25 13:23:17
2-Nitrophenylacetonitrile Structural

What is 2-Nitrophenylacetonitrile?

Chemical properties

Yellow Solid

The Uses of 2-Nitrophenylacetonitrile

2-Nitrophenylacetonitrile was used in synthesis of 2 or 2,4-substituted α-carbolines via a one-pot tandem reaction of α,β-unsaturated ketones. It was used in the synthesis of strychnine.

Synthesis Reference(s)

Synthesis, p. 514, 1987 DOI: 10.1055/s-1987-27989

General Description

Light brown solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Nitriles, such as 2-Nitrophenylacetonitrile, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.

Fire Hazard

Flash point data for 2-Nitrophenylacetonitrile are not available. 2-Nitrophenylacetonitrile is probably combustible.

Properties of 2-Nitrophenylacetonitrile

Melting point: 82-85 °C(lit.)
Boiling point: 178°C
Density  1.3264 (rough estimate)
refractive index  1.5770 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Chloroform, Ethyl Acetate
form  Powder
color  Light brown to brownish-gray
Water Solubility  <0.01 g/100 mL at 20 ºC
BRN  1869400
Exposure limits NIOSH: IDLH 25 mg/m3
Stability: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 610-66-2(CAS DataBase Reference)
EPA Substance Registry System o-Nitrophenylacetonitrile (610-66-2)

Safety information for 2-Nitrophenylacetonitrile

Signal word Warning
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H311:Acute toxicity,dermal
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H332:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P309:IF exposed or if you feel unwell:
P310:Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-Nitrophenylacetonitrile

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