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HomeProduct name list3-Bromo-2-naphthol

3-Bromo-2-naphthol

3-Bromo-2-naphthol Structural

What is 3-Bromo-2-naphthol?

The Uses of 3-Bromo-2-naphthol

3-Bromo-2-naphthol is an important organic compound with a wide range of applications in the pharmaceutical and chemical industries. It is commonly used in organic synthetic materials to prepare pharmaceutical products, ester compounds, resin compositions, curing products and stacking films; it serves as an important reagent and catalyst in a variety of chemical reactions.

Synthesis

3-Bromo-2-naphthol is synthesised using 2-bromo-3-methoxynaphthalene as a raw material by chemical reaction. The specific synthesis steps are as follows:
General procedure: To a Schlenk flask were added 2-bromo-3-methoxynaphthalene(1.0 equiv), aryl boronic acid (2.2 equiv), K2CO3 (3.0 equiv), Pd(PPh3)4 (2.5 mol%), and degassed EtOH/toluene/water (1/1/1) under Ar atmosphere. The mixture was heated at 90 °C until thecompletion of the reaction. Then the mixture was cooled to room temperature, and DCM was added. The mixture was washed with NaOH solution (20% wt), and the aqueous phase was extracted with DCM (2 × 20 mL). The combined organic phase was washed with brine (20 mL) and dried overanhydrous MgSO4. After removing the solvent, the residue was dissolved in anhydrous DCM. Thesolution was cooled to -78 °C, and BBr3 (1 M in DCM, 5.0 equiv) was added slowly by syringe. Thenthe mixture was warmed up to room temperature and stirred until the complete consumption of thestarting material. The mixture was poured into the ice water (50 mL) and extracted with DCM (3 × 50mL). The combined organic phase was washed with brine (100 mL) and dried over anhydrous Na2SO4. After removing the solvent, the residue was purified by silica gel chromatography to give 3-Bromo-2-naphthol.
3-Bromo-2-naphthol synthesis

Properties of 3-Bromo-2-naphthol

Melting point: 82 °C
Boiling point: 313.7±15.0 °C(Predicted)
Density  1.614±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
form  powder to crystal
pka 8.03±0.40(Predicted)
color  White to Light yellow
CAS DataBase Reference 30478-88-7

Safety information for 3-Bromo-2-naphthol

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H318:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.

Computed Descriptors for 3-Bromo-2-naphthol

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