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HomeProduct name list2-METHYLISONICOTINALDEHYDE

2-METHYLISONICOTINALDEHYDE

2-METHYLISONICOTINALDEHYDE Structural

What is 2-METHYLISONICOTINALDEHYDE?

The Uses of 2-METHYLISONICOTINALDEHYDE

2-Methylisonicotinaldehyde belongs to the pyridine group of compounds and is used in the preparation of benzimidazoles and related analogues as sirtuin modulators and in the synthesis of other organic compounds.

Synthesis

2-Methylisonicotinaldehyde is synthesised using methanol as raw material by chemical reaction. The specific synthesis steps are as follows:
A solution of N,N-dimethyl-2-(2-methyl-4-pyridyl)ethenamine (6.4 g, 39 mmol) in methanol (25 ml) was added dropwise to a mixture of sodium periodate (25.2 g, 117 mmol) and methanol (25 ml) at room temperature.. The mixture was stirred at the same temperature for 1 hr.. The precipitates were filtered off, and the filtrate was concentrated.. The residue was combined with water and extracted with ethyl acetate.. The organic layer was washed with saturated brine and dried over magnesium sulfate.. The solvent was evaporated to give the titled compound (3.7 g, 78 percent).1H-NMR (CDCl3) δ: 2.68 (3H, s), 7.51 (1H, d, J = 4.9 Hz), 7.56 (1H, s), 8.76 (1H, d, J = 4.9 Hz), 10.05 (1H, s).
2-METHYLISONICOTINALDEHYDE synthesis

Properties of 2-METHYLISONICOTINALDEHYDE

Melting point: 83 °C
Boiling point: 53-54 °C(Press: 0.5 Torr)
Density  1.095±0.06 g/cm3(Predicted)
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
pka 3.98±0.10(Predicted)

Safety information for 2-METHYLISONICOTINALDEHYDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-METHYLISONICOTINALDEHYDE

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