2-METHYL-M-PHENYLENE DIISOCYANATE

Synonym(s):2-Methyl-m-phenylene diisocyanate;Tolylene-2,6-diisocyanate

CAS NO.：91-08-7
Empirical Formula: C9H6N2O2
Molecular Weight: 174.16
MDL number: MFCD00002010
EINECS: 202-039-0
SAFETY DATA SHEET (SDS)
Update Date: 2023-08-15 17:37:19

2-METHYL-M-PHENYLENE DIISOCYANATE Structural

What is 2-METHYL-M-PHENYLENE DIISOCYANATE?

Chemical properties

colourless liquid

The Uses of 2-METHYL-M-PHENYLENE DIISOCYANATE

2-Methyl-m-phenylene Diisocyanate is used in method for preparing breathable sweat-absorbing EVA foam shoe material.

The Uses of 2-METHYL-M-PHENYLENE DIISOCYANATE

2,6-TDI may be used as a reference standard for the quantification of residual 2,6-TDI in foam samples using high performance liquid chromatography coupled to coordination-ionspray tandem mass spectrometry (HPLC-CIS-MS/MS).

Definition

ChEBI: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 6 relative to the methyl group on the benzene ring.

Synthesis Reference(s)

The Journal of Organic Chemistry, 60, p. 257, 1995 DOI: 10.1021/jo00106a044

General Description

Liquid. Used in the manufacture of polyurethane foams, elastomers, and coatings; crosslinking agent for nylon 6.

Reactivity Profile

2-METHYL-M-PHENYLENE DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. [Handling Chemcials Safely 1980. p. 907]. Reaction with water to form Carbon Dioxide [Merck 11th ed. 1989].

Health Hazard

Classified as slightly toxic orally. Probable oral lethal dose in humans is 5 to 15 g/kg or between 1 pint and 1 quart for a 70 (l50 lb.) person. Particularly poisonous when breathed. This is among the most poisonous of isocyanates. Acute and chronic exposures to low concentrations may produce asthmatic attacks.

Fire Hazard

When heated to decomposition, 2-METHYL-M-PHENYLENE DIISOCYANATE emits toxic fumes of nitrogen oxides. Ventilation should be adequate. If polyurethane products are heated, protection against isocyanate release is necessary. Avoid decomposing heat.

Flammability and Explosibility

Non flammable

Safety Profile

Confirmed carcinogen. Poison by ingestion and inhalation. Human systemic effects by inhalation: olfactory, eye, and pulmonary changes. Flammable liquid. When heated to decomposition it emits toxic fumes of NOx. See also CYANATES.

Purification Methods

It is purified by fractional distillation in a vacuum. Store it under N2 in sealed dark ampoules as it is water and light sensitive. Like the preceding 2,4-isomer, it has a sharp pungent odour, is TOXIC and is IRRITATING TO THE EYES. [Beilstein 13 IV 259.]

Properties of 2-METHYL-M-PHENYLENE DIISOCYANATE

Melting point:	13°C
Boiling point:	129-133 °C18 mm Hg(lit.)
Density	1.225 g/mL at 25 °C(lit.)
vapor pressure	2.78Pa at 25℃
refractive index	n20/D 1.571(lit.)
Flash point:	>230 °F
storage temp.	−20°C
form	Liquid
color	Clear colorless to light yellow
Water Solubility	It hydrolyzes in water.
Sensitive	Moisture Sensitive
BRN	2211546
Exposure limits	ACGIH: TWA 0.001 ppm; STEL 0.005 ppm (Skin)
Stability:	Stability Reacts violently with water. Reacts very rapidly with compounds containing an active hydrogen, such as amines, alcohols and acids. Polymerizes rapidly in the presence of base. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	91-08-7(CAS DataBase Reference)
EPA Substance Registry System	Toluene-2,6-diisocyanate (91-08-7)

Safety information for 2-METHYL-M-PHENYLENE DIISOCYANATE

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H330:Acute toxicity,inhalation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H351:Carcinogenicity H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.