Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list2-Methoxyethoxymethyl chloride

2-Methoxyethoxymethyl chloride

Synonym(s):β-Methoxyethoxymethyl chloride;MEM-chloride

  • CAS NO.:3970-21-6
  • Empirical Formula: C4H9ClO2
  • Molecular Weight: 124.57
  • MDL number: MFCD00000888
  • EINECS: 223-589-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:15:30
2-Methoxyethoxymethyl chloride Structural

What is 2-Methoxyethoxymethyl chloride?

Chemical properties

CLEAR COLOURLESS LIQUID

The Uses of 2-Methoxyethoxymethyl chloride

2-Methoxyethoxymethyl Chloride is an OH-protecting reagent. 2-Methoxyethoxymethyl Chloride is used in the modification of antibiotics.

The Uses of 2-Methoxyethoxymethyl chloride

2-Methoxyethoxymethyl chloride, is used as selectively cleaved under aprotic conditions in the presence of a wide range of OH-protected reagents. It is used as an OH-protecting reagent. An examples of the target molecule MEM Chloride is the side chain of roxithromycin. It is also used in the protection of the OH groups in serine and threonine during peptide synthesis. Some of the other applications include have the ability to coordinate to metals, which is thought to accelerate the cleavage by Lewis acids. The chelating ability of the MEM ether also makes it useful as a stereodirecting group in organometallic reactions, first noted in the stereo controlled addition of ?-methoxyvinyllithium to a carbonyl in the synthesis of taxusin.

The Uses of 2-Methoxyethoxymethyl chloride

OH-protecting reagent. MEM ethers are stable to a variety of reaction conditions and are selectively cleaved under aprotic conditions in the presence of a wide rangeof OH-protected moieties.

What are the applications of Application

2-Methoxyethoxymethyl chloride is a useful reagent for creating protecting groups

Purification Methods

Possible impurities are methoxyethanol (b 124o/atm), HCHO and HCl which can be removed below the boiling point of MEMCl. Purify MEMCl by fractional distillation in a vacuum. If too impure, prepare it from methoxyethanol (152g) and s-trioxane (66g) by bubbling a stream of dry HCl (with stirring) until a clear mixture is obtained. Dilute with pentane (900mL), dry (3hours over 100g MgSO4, at 5o), evaporate and the residue is distilled in a vacuum. It is MOISTURE SENSITIVE and TOXIC. The MEM.NEt3+Cl-salt, prepared by reaction with 1.3 equivalents of Et3N (16hours/25o) and dried in a vacuum, has m 58-61o, and is moisture sensitive. [Corey et al. Tetrahedron Lett 809 1976, Yoshimatsu et al. J Org Chem 59 1011 1994, Greene & Wuts Protective Groups in Organic Synthesis edn, J Wiley & Sons NY 1991.] Carcinogen.

Properties of 2-Methoxyethoxymethyl chloride

Melting point: 200-202 °C
Boiling point: 50-52 °C/13 mmHg (lit.)
Density  1.091 g/mL at 25 °C (lit.)
refractive index  n20/D 1.427(lit.)
Flash point: >230 °F
storage temp.  2-8°C
solubility  Chloroform, Methanol
form  Liquid
color  Clear colorless to yellow
Specific Gravity 1.091
Water Solubility  It hydrolyzes with water.
Sensitive  Moisture Sensitive
BRN  1900576
Exposure limits ACGIH: TWA 0.001 ppm
CAS DataBase Reference 3970-21-6(CAS DataBase Reference)
NIST Chemistry Reference «BETA»-methoxyethoxymethyl chloride(3970-21-6)
EPA Substance Registry System Ethane, 1-(chloromethoxy)-2-methoxy- (3970-21-6)

Safety information for 2-Methoxyethoxymethyl chloride

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H226:Flammable liquids
H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H331:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H350:Carcinogenicity
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for 2-Methoxyethoxymethyl chloride

InChIKey BIAAQBNMRITRDV-UHFFFAOYSA-N

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.