2-Methoxy-4-methylphenol
Synonym(s):2-Hydroxy-5-methylanisole;2-Methoxy-p-cresol;4-Hydroxy-3-methoxytoluene;4-Methylguaiacol;Creosol
- CAS NO.:93-51-6
- Empirical Formula: C8H10O2
- Molecular Weight: 138.16
- MDL number: MFCD00002378
- EINECS: 202-252-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-16 15:01:30
What is 2-Methoxy-4-methylphenol?
Description
2-Methoxy-4-methylphenol has a characteristic aromatic odor (sweet, spicy, slightly vanilla-like) and a somewhat bitter taste (vanilla-like). May be prepared by methylation of homopyrocatechin using dimethyl sulfate and alkali; also by hydrogenation of vanillin.
Chemical properties
2-Methoxy-4-methylphenol is a clear colorless to slightly yellow liquid or viscous, yeelowish oil, solidifying in the cold. The prismatic crystals melt at 6° C. Sp.Gr. 1.10. B.P. 222° C. Very slightly soluble in water, soluble in alcohol and oils. Sweet-spicy, phenolic-leathery odor with distinctly Vanilla-1ike undertones, balsamicwarm sweetness, but overall too medicinal to become classified as a versatile, floral-balsamic ingredient.
Chemical properties
2-Methoxy-4-methylphenol has a characteristic aromatic odor (sweet, spicy, slightly vanilla-like) and a somewhat bitter taste (vanilla-like).
Occurrence
Occurs in beechwood tar; also identified in the essential oils of ylang-ylang, jasmine and anise seeds; it is one of the active constituents of creosote. Reported found in Gruyere cheese, smoked fish, cured pork, beer, rum, bourbon whiskey, malt and Scotch whiskey, sherry, white and red wine, cocoa, coffee, tea, mushrooms, mango, pear brandy, malt, wort, dried bonito, Bourbon vanilla, cuttlefish and green maté.
The Uses of 2-Methoxy-4-methylphenol
2-Methoxy-4-methylphenol is used for blending baking and smoked food flavors.
The Uses of 2-Methoxy-4-methylphenol
2-Methoxy-4-methylphenol is used in preparation of renewable bis(cyanate) esters.
Preparation
By methylation of homopyrocatechin using dimethyl sulfate and alkali; also by hydrogenation of vanillin.
Definition
ChEBI: 2-Methoxy-4-methylphenol is a member of phenols and a member of methoxybenzenes.
Production Methods
With three distinct oxygenated functional groups (aldehyde, ether, and hydroxyl), VAN can undergo selective hydrodeoxygenation to produce 2- methoxy-4-methylphenol (MMP), a promising candidate for future biofuel applications and its use in fragrances and intermediate in pharmaceutical synthesis. Kumar et al. developed stable, cost-effective Ni nanoparticles supported on montmorillonite (MMT) clay, which was synthesized for eco-friendly, alcohol-mediated catalytic transfer hydrodeoxygenation of VAN to MMP. The Ni(10%)/MMT catalyst achieved >99% VAN conversion and 95.2% MMP selectivity using isopropanol (IPA) as a solvent and hydrogen donor[1].
References
[1] Atul Kumar, Prof. Dr. Rajendra Srivastava, Dr. Rajaram Bal. “Ni Nanoparticles Supported Montmorillonite Clay for Selective Catalytic Transfer Hydrodeoxygenation of Vanillin into 2-Methoxy-4-methylphenol.” ChemCatChem 16 9 (2024).
Aroma threshold values
Detection: 90 ppb. Aroma characteristics at 1.0%: smoky, sweet, phenolic, vanilla, spicy clove with a floral carnation nuance.
Taste threshold values
Taste characteristics at 1.0 to 1.25 ppm: sweet phenolic, spice, vanilla, medicinal, clove-like, smoky, guaia col-like with a woody, phenolic nuance.
General Description
2-Methoxy-4-methylphenol is the major component of black-ripe table olive aroma. It is the major anti-inflammatory compound in bamboo vinegar. Kinetics of reaction of 2-methoxy-4-methylphenol with chlorine atoms was studied.
Biochem/physiol Actions
Odor at 1.0%
Properties of 2-Methoxy-4-methylphenol
Melting point: | 5 °C (lit.) |
Boiling point: | 221-222 °C (lit.) |
Density | 1.092 g/mL at 25 °C (lit.) |
refractive index | n |
FEMA | 2671 | 2-METHOXY-4-METHYLPHENOL |
Flash point: | 211 °F |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Chloroform (Sparingly), Methanol (Slightly) |
form | Liquid |
pka | 10.27±0.18(Predicted) |
Specific Gravity | 1.091.092 |
color | colorless to light yellow |
Odor | at 10.00 % in dipropylene glycol. spicy clove vanilla phenolic medicinal leathery woody smoky burnt |
Water Solubility | Slightly soluble in water. |
JECFA Number | 715 |
Merck | 14,2571 |
BRN | 1862340 |
Dielectric constant | 11.0 |
CAS DataBase Reference | 93-51-6(CAS DataBase Reference) |
NIST Chemistry Reference | Phenol, 2-methoxy-4-methyl-(93-51-6) |
EPA Substance Registry System | Phenol, 2-methoxy-4-methyl- (93-51-6) |
Safety information for 2-Methoxy-4-methylphenol
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Methoxy-4-methylphenol
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