2-Iodoacetamide
Synonym(s):α-Iodoacetamide - CAS 144-48-9 - Calbiochem;2-Iodoacetamide
- CAS NO.:144-48-9
- Empirical Formula: C2H4INO
- Molecular Weight: 184.96
- MDL number: MFCD00008028
- EINECS: 205-630-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-20 11:47:35
What is 2-Iodoacetamide?
The Uses of 2-Iodoacetamide
2-Iodoacetamide is an alkylating reagent for cysteine residues in peptide sequencing. Its actions are similar to those of iodoacetate. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibition of ribonuclease.
What are the applications of Application
α-Iodoacetamide is an electrophilic acetamide useful for protein modification
Properties of 2-Iodoacetamide
Melting point: | 92-95 °C(lit.) |
Boiling point: | 297.1±23.0 °C(Predicted) |
Density | 2.1103 (estimate) |
storage temp. | 2-8°C |
solubility | Soluble in water, dimethyl formamide and ethanol. Slightly soluble in methanol. |
form | crystalline |
color | White to pale yellow or beige |
Water Solubility | H2O: 0.5M at 20°C, clear, colorless |
Sensitive | Light Sensitive |
Safety information for 2-Iodoacetamide
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H301:Acute toxicity,oral H317:Sensitisation, Skin H334:Sensitisation, respiratory H413:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for 2-Iodoacetamide
InChIKey | PGLTVOMIXTUURA-UHFFFAOYSA-N |
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