2-(HYDROXYMETHYL)-12-CROWN 4-ETHER
Synonym(s):(12-Crown-4)-2-methanol;1,4,7,10-Tetraoxacyclododecan-2-methanol
- CAS NO.:75507-26-5
- Empirical Formula: C9H18O5
- Molecular Weight: 206.24
- MDL number: MFCD00067524
- EINECS: 278-224-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 2-(HYDROXYMETHYL)-12-CROWN 4-ETHER?
Chemical properties
CLEAR COLOURLESS VISCOUS LIQUID
The Uses of 2-(HYDROXYMETHYL)-12-CROWN 4-ETHER
Ethylene oxide is important or critical to the production of detergents, thickeners, solvents, plastics, and various organic chemicals such as ethylene glycol, ethanolamines, simple and complex glycols, polyglycol ethers and other compounds.
The Uses of 2-(HYDROXYMETHYL)-12-CROWN 4-ETHER
2-Hydroxymethyl-12-crown-4 can be used:
- To prepare an ester of lasalocid with crown ether to study its complex formation with monovalent cations.
- To prepare hydrogel adsorbents for potential usage in the recovery of lithium-ions from seawater.
- As a starting material in the synthesis of metal-free phthalocyanines and metallophthalocyanines.
Purification Methods
Purify it by chromatography on Al2O3 with EtOAc as eluent to give a hygroscopic colourless oil, which is distilled under high vacuum and is distilled in vacuo. It has IR: 3418 (OH) and 1103 (COC) cm-1, NMR: max 3.70s. [Kimura et al. J Chem Soc, Chem Commun 492 1983, Pugia et al. J Org Chem 52 2617 1987.] S -(-)-5-Hydroxymethyl -2(5 H )-furanone [78508-96 -0] M 114.1, 39 -42o, 40 -44o , b 1 3 0o/0.3mm, [ ] 546 -180o, [ ] D -148o (c 1.4, H2O). It is purified by chromatography on Silica gel using hexane/EtOAc (1:1) to give a colourless oil which is distilled using a Kügelrohr apparatus, and the distillate crystallises on cooling. It has RF 0.51 on Whatman No 1 paper using pentan-1-ol and 85% formic acid (1:1) and developing with ammoniacal AgNO3. [Boll Acta Chem Scand 22 3245 1968, NMR: Oppolzer et al. Helv Chim Acta 68 2100 1985, Beilstein 18 III/IV 56, 18/1 V 54.]
Properties of 2-(HYDROXYMETHYL)-12-CROWN 4-ETHER
Boiling point: | 115 °C/0.04 mmHg (lit.) |
Density | 1.192 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | >230 °F |
form | Liquid |
pka | 14.17±0.10(Predicted) |
Specific Gravity | 1.2 |
color | Colorless to Light yellow |
Water Solubility | Miscible in water. Soluble in non-polar solvents. Insoluble in water. |
BRN | 4661968 |
CAS DataBase Reference | 75507-26-5(CAS DataBase Reference) |
Safety information for 2-(HYDROXYMETHYL)-12-CROWN 4-ETHER
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-(HYDROXYMETHYL)-12-CROWN 4-ETHER
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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