12-Crown-4
Synonym(s):1,4,7,10-Tetraoxacyclododecane
- CAS NO.:294-93-9
- Empirical Formula: C8H16O4
- Molecular Weight: 176.21
- MDL number: MFCD00005103
- EINECS: 206-036-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 12-Crown-4?
Chemical properties
clear colorless to slightly yellow liquid after
The Uses of 12-Crown-4
12-Crown-4 can be used as:
- A promoter in the synthesis of poly(diethylsiloxane) (PDES) from monomer hexaethylcyclotrisiloxane using NaOH as a catalyst via anionic ring-opening polymerization.
- As an additive in the preparation of triarylmethane derivatives by palladium-catalyzed cross coupling reaction of aryl bromides with diarylmethane derivatives.
- A phase transfer catalyst in organic synthesis.
The Uses of 12-Crown-4
It serves as an aprotic "solvent" for alkali metals, the sodium solution is a strong reducing agent.
What are the applications of Application
12-Crown-4 is an aprotic "solvent" for alkali metals, the sodium solution is a strong reducing agent
Definition
ChEBI: A crown ether that is cyclododecane in which the carbon atoms at positions 1, 4, 7 and 10 have been replaced by oxygen atoms.
Synthesis Reference(s)
Tetrahedron Letters, 15, p. 4029, 1974 DOI: 10.1016/S0040-4039(01)92075-1
General Description
12-Crown-4 is a crown ether generally used as a ligand in coordination chemistry. It is also known as lithium ionophore because of its strong chelating property specific to lithium cation.
Purification Methods
The distilled crude product has to be recrystallised from pentane at -20o to remove acyclic material. It is then dried over P2O5. It complexes Li. [Anet et al. Acta Chem Scand 27 3395 1973, Beilstein 19/11 V 334.]
Properties of 12-Crown-4
Melting point: | 16 °C (lit.) |
Boiling point: | 61-70 °C/0.5 mmHg (lit.) |
Density | 1.089 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
form | Liquid After Melting |
Specific Gravity | 1.115 (20℃) |
color | Clear colorless to slightly yellow |
Water Solubility | MISCIBLE |
Sensitive | Air Sensitive |
BRN | 1363064 |
CAS DataBase Reference | 294-93-9(CAS DataBase Reference) |
NIST Chemistry Reference | 12-Crown-4(294-93-9) |
EPA Substance Registry System | 1,4,7,10-Tetraoxacyclododecane (294-93-9) |
Safety information for 12-Crown-4
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H330:Acute toxicity,inhalation |
Computed Descriptors for 12-Crown-4
Abamectin manufacturer
Dr. Silviu Pharmachem Pvt., Ltd.
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