2-Hydroxy-5-pyridinecarboxylic acid

Synonym(s):2-Hydroxy-5-pyridinecarboxylic acid;6-Hydroxynicotinic acid;6-Hydroxypyridine-3-carboxylic acid

CAS NO.：5006-66-6
Empirical Formula: C6H5NO3
Molecular Weight: 139.11
MDL number: MFCD00006277
EINECS: 225-682-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

2-Hydroxy-5-pyridinecarboxylic acid Structural

What is 2-Hydroxy-5-pyridinecarboxylic acid?

Chemical properties

Off-white powder

The Uses of 2-Hydroxy-5-pyridinecarboxylic acid

6-Hydroxynicotinic acid is used as building block in chemical synthesis.

The Uses of 2-Hydroxy-5-pyridinecarboxylic acid

Nicotinic Acid derivative, found in fruit hypanthium.

The Uses of 2-Hydroxy-5-pyridinecarboxylic acid

Metabolite of nicotinamide. Stimulates adrenocortical secretion

Definition

ChEBI: A monohydroxypyridine that is the 6-hydroxy derivative of nicotinic acid.

General Description

6-Hydroxypyridine-3-carboxylic acid (6-Hydroxynicotinic acid) reacts with Ln(2)O(3) (Ln = Nd, Sm, Eu, Gd) and oxalic acid (H(2)OX) to generate four novel lanthanide-organic coordination polymeric networks.

Purification Methods

It crystallises from water with m 303.4-303.7o(dec), or with m 325o(dec) from aqueous EtOH. The methyl ester crystallises from Me2CO with m 166o and pK2 0 9.92. [Albert J Chem Soc 1020 1960, Beilstein 22 III/IV 2147, 22/6 V 119.]

Properties of 2-Hydroxy-5-pyridinecarboxylic acid

Melting point:	>300 °C (lit.)
Boiling point:	255.04°C (rough estimate)
Density	1.4429 (rough estimate)
refractive index	1.5423 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
form	Powder
pka	3.80±0.50(Predicted)
color	Off-white to light brown
BRN	472182
InChI	InChI=1S/C6H5NO3/c8-5-2-1-4(3-7-5)6(9)10/h1-3H,(H,7,8)(H,9,10)
CAS DataBase Reference	5006-66-6(CAS DataBase Reference)
EPA Substance Registry System	6-Hydroxynicotinic acid (5006-66-6)

Safety information for 2-Hydroxy-5-pyridinecarboxylic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.