2-Hydroxy-5-pyridinecarboxylic acid
Synonym(s):2-Hydroxy-5-pyridinecarboxylic acid;6-Hydroxynicotinic acid;6-Hydroxypyridine-3-carboxylic acid
- CAS NO.：5006-66-6
- Empirical Formula: C6H5NO3
- Molecular Weight: 139.11
- MDL number: MFCD00006277
- EINECS: 225-682-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-22 14:18:24
What is 2-Hydroxy-5-pyridinecarboxylic acid?
Chemical properties
Off-white powder
The Uses of 2-Hydroxy-5-pyridinecarboxylic acid
6-Hydroxynicotinic acid is used as building block in chemical synthesis.
The Uses of 2-Hydroxy-5-pyridinecarboxylic acid
Nicotinic Acid derivative, found in fruit hypanthium.
The Uses of 2-Hydroxy-5-pyridinecarboxylic acid
Metabolite of nicotinamide. Stimulates adrenocortical secretion
Definition
ChEBI: A monohydroxypyridine that is the 6-hydroxy derivative of nicotinic acid.
General Description
6-Hydroxypyridine-3-carboxylic acid (6-Hydroxynicotinic acid) reacts with Ln(2)O(3) (Ln = Nd, Sm, Eu, Gd) and oxalic acid (H(2)OX) to generate four novel lanthanide-organic coordination polymeric networks.
Purification Methods
It crystallises from water with m 303.4-303.7o(dec), or with m 325o(dec) from aqueous EtOH. The methyl ester crystallises from Me2CO with m 166o and pK2 0 9.92. [Albert J Chem Soc 1020 1960, Beilstein 22 III/IV 2147, 22/6 V 119.]
Properties of 2-Hydroxy-5-pyridinecarboxylic acid
| Melting point: | >300 °C (lit.) |
| Boiling point: | 255.04°C (rough estimate) |
| Density | 1.4429 (rough estimate) |
| refractive index | 1.5423 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Powder |
| pka | 3.80±0.50(Predicted) |
| color | Off-white to light brown |
| BRN | 472182 |
| InChI | InChI=1S/C6H5NO3/c8-5-2-1-4(3-7-5)6(9)10/h1-3H,(H,7,8)(H,9,10) |
| CAS DataBase Reference | 5006-66-6(CAS DataBase Reference) |
| EPA Substance Registry System | 6-Hydroxynicotinic acid (5006-66-6) |
Safety information for 2-Hydroxy-5-pyridinecarboxylic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Hydroxy-5-pyridinecarboxylic acid
| InChIKey | BLHCMGRVFXRYRN-UHFFFAOYSA-N |
| SMILES | C1NC(=O)C=CC=1C(O)=O |
2-Hydroxy-5-pyridinecarboxylic acid manufacturer
GK Chemicals
1Y
Phone:+91-7207279444
Whatsapp: +91-7207279444
product: 6-Hydroxy Nicotinic Acid 5006-66-6 98%
SAKEM LLP
1Y
Phone:+91-9676889998
Whatsapp: +91-9676889998
product: 5006-66-6 6-Hydroxy Nicotinic Acid 98%
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