2-Hydroxy-3-trifluoromethylpyridine

CAS NO.：22245-83-6
Empirical Formula: C6H4F3NO
Molecular Weight: 163.1
MDL number: MFCD00153194
EINECS: 671-273-7
SAFETY DATA SHEET (SDS)
Update Date: 2025-03-07 08:52:18

What is 2-Hydroxy-3-trifluoromethylpyridine?

Description

2-hydroxy-3-(trifluoromethyl)pyridine (or 3-(Trifluoromethyl)-2-pyridone) is a trifluoromethyl substituted 2-hydroxypyridine. It is used as a synthesis intermediate for ligands and bioactive ingredients in the application of drug discovery and catalytic reactions. In catalytic reactions, the amide group of 2-pyridone binds to transition metals, forming stable 5-/6-membered ring intermediates. Hence, 2-hydroxy-3-(trifluoromethyl)pyridine is widely used as a ligand in catalytic reactions such as directed C-H activation on meta-position. In addition, the trifluoromethyl substituent of 3-(trifluoromethyl)-2-pyridone tunes its metal-binding affinity and limits the reaction site for improving regioselectivity.

Chemical properties

White powder

The Uses of 2-Hydroxy-3-trifluoromethylpyridine

2-Hydroxy-3-trifluoromethylpyridine is a reactant in the synthesis of Pyrido[2,3-b]pyrazine, a TRPV1 antagonist .

Properties of 2-Hydroxy-3-trifluoromethylpyridine

Melting point:	150-153°C
Boiling point:	223.7±40.0 °C(Predicted)
Density	1.398±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
form	powder to crystal
pka	9.67±0.10(Predicted)
color	White to Almost white
InChI	InChI=1S/C6H4F3NO/c7-6(8,9)4-2-1-3-10-5(4)11/h1-3H,(H,10,11)
CAS DataBase Reference	22245-83-6(CAS DataBase Reference)

Safety information for 2-Hydroxy-3-trifluoromethylpyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.